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Liver and intrahepatic bile ducts-nontumor


Chronic hepatitis - general

Reviewers: Komal Arora, M.D. (see Reviewers page)
Revised: 30 April 2012, last major update April 2012
Copyright: (c) 2004-2012, PathologyOutlines.com, Inc.


Chronic hepatitis with piecemeal (periportal) necrosis:
● Also called interface hepatitis
● Formerly called chronic active hepatitis
● Patients with liver disease 6 months or more and portal-based inflammation, fibrosis, disruption of terminal plate and piecemeal necrosis (necrosis of isolated hepatocytes)
● Also periportal hepatocyte rosettes due to regeneration
● May have ballooned hepatocytes and peripheral apoptotic bodies
● Collagen deposition occurs in periportal zone forming septa that extend into lobule in holly-leaf pattern
● No prominent ductular proliferation except in severe lesions

Chronic hepatitis without piecemeal necrosis:
● Formerly called chronic persistent hepatitis or chronic lobular hepatitis (if focal hepatocyte apoptosis)

Micro images

Piecemeal necrosis in hepatitis B

Piecemeal necrosis in chronic hepatitis

End of Liver and intrahepatic bile ducts-nontumor > Hepatitis > Chronic hepatitis - general

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