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Skin - Nonmelanocytic tumors

Adnexal tumors - eccrine sweat glands

Chondroid syringoma


Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 3 July 2012, last major update June 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
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● Also known as eccrine mixed tumor (mixed tumor of skin, cutaneous mixed tumor)
● Apocrine mixed tumor variant likely distinct entity (Am J Dermatopathol 2009;31:772)
● Usually benign
● Face, head, neck > extremities, trunk or back
● Calcification/ossification may occur

Case reports
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● 29 year old man with one year history of right scalp mass (Dermatol Online J 2012;18:9)
● 43 year old woman with slowly growing right arm mass (Dermatol Online J 2006;12:14)

Gross description
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● Nodular, circumscribed, nonulcerated

Clinical / gross images
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29 year old man with one year history of right scalp mass

Micro description
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● Myoepithelial and epithelial type cells, some with abundant hyaline cytoplasm, in chrondomyxoid stroma
● May have eosinophilic globules with radiating fibrillary structures around their lumina, similar to mammary collagenous spherulosis

Micro images
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Contributed by Angel Fernandez-Flores, MD, PhD, Hospital El Bierzo and Clinica Ponferrada, Spain


Well circumscribed dermal nodule with glandular and stromal components, but no attachment to epidermis


Epithelial component is bland, with 2 cell layers and ductule formation; stroma has streaming fibroblast-like cells and is fibrotic

Positive stains
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Inner epithelial layer keratin, EMA, CEA
Outer myoepithelial layer vimentin, S100, NSE
● Variable smooth muscle actin, GFAP

Differential diagnosis
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● Apocrine mixed tumor
● Metastatic carcinoma
● Cutaneous chondroma

End of Skin - Nonmelanocytic tumors > Adnexal tumors - eccrine sweat glands > Chondroid syringoma


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