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Thyroid gland
Thyroiditis
Hashimoto’s thyroiditis

Reviewer: Shahidul Islam, M.D., Ph.D. (see Reviewers page)
Revised: 7 June 2013, last major update March 2009
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

See also fibrous (fibrosing) variant, fibrous atrophy variant below

General
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Terminology
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Epidemiology
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Clinical features
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Laboratory
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Case reports
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Treatment
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Gross description
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Gross images
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Atrophic gland
Symmetrical enlargement with lobular yellow-gray color (AFIP)
Nodular gland

Images contributed by Dr. Mark R. Wick:
With large cell lymphoma
Micro description
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Micro images
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Nodular gland with prominent lymphoid follicles
Atrophic thyroid follicles and prominent lymphoid follicles
Lymphoid follicle and prominent Hürthle cells
With residual Graves’ disease
Lymphocytes, plasma cells, Hürthle cells and giant cells
Chronic inflammation and Hürthle cells
Oxyphilic degeneration of epithelium
Prominent lymphoid follicles, abundant colloid in this section
Lymphoplasmacellular inflammation, destroyed follicles with sparse colloid, prominent Hurthle cells
H&E, CD3
CD68+ giant cells
Antimicrosomal antibody
Antithyroglobulin antibody

Images from AFIP:
Squamous lined cyst
Clear cell change
Clear nuclei
Circumscribed nodules
Benign follicular nodule

Images from Dr. Mark R. Wick:
Hashimoto's thyroiditis
Branchial cyst-like change
With large cell lymphoma
Sclerosing variant
With marginal zone lymphoma
With sequestered thyroid nodule
Virtual slides
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Numerous large germinal centers
Cytology description
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Cytology images
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Lymphoid and follicular epithelial cells
Oncocytic cells with atypical nuclei
Sheet of follicular cells with oncocytic change mixed with benign lymphoid cells (third image also has giant cells)
Resembles lymphoma
Grade I: mild lymphocytic inflammatory infiltrate
Grade II: moderate lymphocytic inflammation
Grade III - marked inflammation with polymorphous lymphocytes
Thin Prep versus pap stain
Positive stains
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Electron microscopy description
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Molecular / cytogenetics description
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Videos
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"Histopathology Thyroid--Hashimoto thyroiditis"
by John R. Minarcik, M.D.

Differential diagnosis
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Additional references
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Fibrous (fibrosing) variant of Hashimoto’s thyroiditis
General
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Laboratory
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Treatment
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Gross description
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Micro description
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Micro images
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Images from AFIP:
Metaplastic squamous follicles
Dilated lumen of metaplastic follicle

Various images
Differential diagnosis
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Fibrous atrophy variant of Hashimoto’s thyroiditis
General
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Micro description
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End of Thyroid gland > Thyroiditis > Hashimoto’s thyroiditis


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