Thyroid gland
Other carcinoma
Sclerosing mucoepidermoid carcinoma with eosinophilia

Author: Shahidul Islam, M.D., Ph.D. (see Authors page)

Revised: 16 February 2017, last major update March 2009

Copyright: (c) 2003-2017,, Inc.

PubMed Search: sclerosing mucoepidermoid carcinoma with eosinophilia

Cite this page: Sclerosing mucoepidermoid carcinoma with eosinophilia. website. Accessed February 25th, 2017.
Definition / General
  • Extensive sclerosis, squamous and glandular differentiation, inflammatory infiltrate rich in eosinophils and background of lymphocytic thyroiditis (Am J Surg Pathol 1991;15:438)
  • Rare; different histogenesis from mucoepidermoid carcinoma of salivary gland (Mod Pathol 2000;13:802)
  • May derive from ultimobranchial body rests (Mod Pathol 2004;17:526)
  • May have aggressive behavior with extrathyroidal extension and distant metastases, but death is rare
  • Almost always women
  • Associated with Hashimoto thyroiditis and ultimobranchial body hyperplasia
Case Reports
Gross Description
  • White, homogenous, firm, usually ill defined
Gross Images

Images hosted on PathOut server:

Well circumscribed tumor (not typical) with dense fibrosis (AFIP)

Mucoepidermoid carcinoma,
sclerosing type,
contributed by Dr. Mark R. Wick

Images hosted on other servers:

Grayish white tumor

Micro Description
  • Diffusely infiltrating tumor with solid / nested growth pattern of squamoid tumor cells with mild to moderate atypia in dense fibrohyaline stroma with marked eosinophil infiltration
  • Small mucin pools present; background of chronic lymphocytic thyroiditis
  • Often vascular and perineural invasion; may have focal clear cells (Ann Diagn Pathol 2003;7:348)
Micro Images

Images hosted on PathOut server:

Small irregular strands of tumor cells (AFIP)

Images hosted on other servers:

Various images

Tumor cells with a keratin pearl

Positive Stains
Negative Stains