Epithelial tumors
Squamous papilloma-conjunctiva

Topic Completed: 1 December 2014

Minor changes: 18 February 2021

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PubMed Search: Squamous papilloma conjunctiva [title]

Deepali Jain, M.D.
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Cite this page: Jain D. Squamous papilloma-conjunctiva. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/eyepapillomaconjunctiva.html. Accessed March 5th, 2021.
Definition / general
  • Also called conjunctival papilloma
  • Prevalence of 4 - 12%
  • In children, often near caruncle and semilunar fold, often bilateral or multiple, recurs after excision
  • In adults, often near limbus, usually solitary, may grow over cornea; may clinically resemble squamous cell carcinoma
  • HPV infection by direct human contact, HPV type 11 most common
  • Less commonly associated with HPV 6a and 45 (Br J Ophthalmol 2007;91:1014)
  • Also UV exposure, Vitamin A deficiency, ocular injury, chemical injury
Clinical features
  • Bulbar or palpebral conjunctival swelling
  • Vascular 'hairpin' loops visible through transparent epithelium
Prognostic factors
  • Recurrence rates of 6 - 27%
Clinical images

Images hosted on other servers:
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Pedunculated red-orange mass of caruncle

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Pedunculated vascular
lesion of conjunctiva
with smooth surface

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Sessile lesion

Gross description
  • Pedunculated, papillary, sessile or mulberry surface on conjunctiva with prominent surface vessels
Microscopic (histologic) description
  • Exophytic growth of papillary, well differentiated, acanthotic nonkeratinized squamous epithelial cells with variable goblet cells supported by prominent, branching fibrovascular core; also inflammation; occasionally koilocytosis, mild dysplastic changes
  • Spindled basosquamous cells; numerous goblet cells; high-level mitoses; no abrupt borders, no glycogen
  • Inverted mucoepidermoid papilloma: endophytic, invaginated lobules of nonkeratinized squamous epithelium with goblet cells; may resemble low grade mucoepidermoid carcinoma
Microscopic (histologic) images

AFIP images
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Limbal tumor composed of fibrovascular
fronds covered by squamous epithelium

Positive stains
Negative stains
Electron microscopy description
Molecular / cytogenetics description
Differential diagnosis
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