Mandible & maxilla
Benign odontogenic tumors
Calcifying epithelial odontogenic tumor
Author: Nat Pernick, M.D.
Last author update: 1 October 2013
Last staff update: 29 December 2020
Copyright: 2004-2023, PathologyOutlines.com, Inc.
PubMed Search: Calcifying epithelial odontogenic tumor [title]
Table of Contents
Definition / general | Sites | Radiology description | Treatment | Case reports | Microscopic (histologic) description | Microscopic (histologic) images | Positive stainsCite this page: Pernick N. Calcifying epithelial odontogenic tumor. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/mandiblemaxillacalcifyingepithelial.html. Accessed March 27th, 2023.
Definition / general
- Also called Pindborg tumor
- Rare
- Ages 30 - 49 years
- May also occur within gingiva (peripheral tumor)
- May be invasive and recur locally, but less aggressive than ameloblastoma
Sites
- Premolar mandible
- Often associated with embedded tooth
Radiology description
- Resembles dentigerous cyst with occasional small radiopacities within large radiolucent area
Treatment
- Less aggressive than ameloblastoma
Case reports
- 62 year old woman with amyloid deposit in calcifying epithelial odontogenic tumor that was immunoreactive for cytokeratins (Arch Pathol Lab Med 2000;124:872)
- 75 year old man with calcifying epithelial odontogenic tumor (J Oral Pathol 1984;13:310)
Microscopic (histologic) description
- Sheets of polyhedral, eosinophilic squamous epithelial cells with focal psammoma bodies
- Variable markedly pleomorphic cells with 2 - 3 nuclei
- Amyloid bodies (containing degenerated keratin filaments)
- Often scanty stroma, although epithelium / stromal ratio is variable between tumors
- Clear cell variant has clear vacuolated cytoplasm
Microscopic (histologic) images
Contributed by Kelly Magliocca, D.D.S., M.P.H.
Calcifying epithelial odontogenic tumor
