Sex cord stromal tumors

Sertoli cell tumor

Last author update: 1 December 2014
Last staff update: 30 May 2023 (update in progress)

Copyright: 2003-2023, PathologyOutlines.com, Inc.

PubMed Search: Sertoli cell tumor[title]

Page views in 2022: 9,099
Page views in 2023 to date: 4,319
Cite this page: Ehdaivand S. Sertoli cell tumor. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/ovarytumorsertoli.html. Accessed June 9th, 2023.
Definition / general
  • Rare; excellent prognosis
  • Mean age 30 years old, range 2-76 years
  • Tends to secrete estrogen / progesterone, but diagnose based on morphology, not hormones
  • Similar to a well differentiated Sertoli-Leydig tumor without a Leydig component; may have abundant cytoplasmic lipid
  • Associated with Peutz-Jeghers syndrome
  • Usually stage I and clinically benign (Am J Surg Pathol 2005;29:143)
Case reports
Gross description
  • Lobulated, solid, yellow-brown, unilateral, mean 9 cm and up to 30 cm
Gross images

AFIP images

Yellow and lobulated

Microscopic (histologic) description
  • Closely packed solid or hollow tubules lined by well-differentiated cuboidal to columnar epithelial cells
  • Few or no Leydig cells, often fibromatous or sclerotic; may have amyloid-like material
  • Other patterns include cord-like and diffuse; variable stroma
  • Occasional cells with bizarre nuclei; minimal mitoses, minimal atypia
  • Malignant: moderate to severe cytologic atypia and 5+ MF/10 HPF
Microscopic (histologic) images

AFIP images

Hollow tubules

Solid tubules

Oxyphilic cell type

Positive stains
  • Inhibin, vimentin, CD99, CD10, AE1-3 or CAM5.2 (usually), calretinin (50%), variable smooth muscle actin and S100
Negative stains
  • EMA, chromogranin
Electron microscopy description
  • Tight junctions, desmosomes, abundant rough endoplasmic reticulum and lipid
Differential diagnosis
Back to top
Image 01 Image 02