Table of Contents
Definition / general | Case reports | Gross description | Gross images | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Negative stains | Electron microscopy description | Differential diagnosisCite this page: Ehdaivand S. Sertoli cell tumor. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/ovarytumorsertoli.html. Accessed June 9th, 2023.
Definition / general
- Rare; excellent prognosis
- Mean age 30 years old, range 2-76 years
- Tends to secrete estrogen / progesterone, but diagnose based on morphology, not hormones
- Similar to a well differentiated Sertoli-Leydig tumor without a Leydig component; may have abundant cytoplasmic lipid
- Associated with Peutz-Jeghers syndrome
- Usually stage I and clinically benign (Am J Surg Pathol 2005;29:143)
Case reports
- 67 year old woman whose tumor has various histologic patterns (Arch Pathol Lab Med 2006;130:e70)
Gross description
- Lobulated, solid, yellow-brown, unilateral, mean 9 cm and up to 30 cm
Gross images
AFIP images
Yellow and lobulated
Microscopic (histologic) description
- Closely packed solid or hollow tubules lined by well-differentiated cuboidal to columnar epithelial cells
- Few or no Leydig cells, often fibromatous or sclerotic; may have amyloid-like material
- Other patterns include cord-like and diffuse; variable stroma
- Occasional cells with bizarre nuclei; minimal mitoses, minimal atypia
- Malignant: moderate to severe cytologic atypia and 5+ MF/10 HPF
Microscopic (histologic) images
AFIP images
Hollow tubules
Solid tubules
Oxyphilic cell type
Positive stains
- Inhibin, vimentin, CD99, CD10, AE1-3 or CAM5.2 (usually), calretinin (50%), variable smooth muscle actin and S100
Negative stains
- EMA, chromogranin
Electron microscopy description
- Tight junctions, desmosomes, abundant rough endoplasmic reticulum and lipid
Differential diagnosis
- Carcinoid: chromogranin+, EMA+ and inhibin-
- Endometrioid carcinoma: EMA+, inhibin-
