Skin nonmelanocytic tumor
Adnexal tumors
Sweat gland derived (apocrine & eccrine glands)

Topic Completed: 1 June 2012

Minor changes: 20 October 2020

Copyright: 2002-2019,, Inc.

PubMed Search: Eccrine acrospiroma [title]

Christopher S. Hale, M.D.
Page views in 2019: 30,867
Page views in 2020 to date: 22,701
Cite this page: Hale C. Hidradenoma. website. Accessed October 21st, 2020.
Definition / general
  • Arises from sweat gland distal excretory duct, usually solitary, on the scalp, axillae
  • Synonyms: Nodular hidradenoma, eccrine acrospiroma
Gross description
  • Nodules with cystic foci high in dermis
Microscopic (histologic) description
  • Nests / lobules of cells resembling eccrine poroma with either clear cytoplasm or prominent squamous metaplasia
  • May have marked vascularity
  • Small and large lumina are lined by cuboidal ductal cells or columnar secretory cells
  • Cystic spaces may be due to degeneration of tumor cells
Microscopic (histologic) images

Images hosted on other servers:

Courtesy of Angel Fernandez-Flores, M.D., Ph.D.

Breast skin - contributed by Mark R. Wick, M.D.

Positive stains
Differential diagnosis
  • Apocrine mixed tumor
  • Glomus tumor (different staining pattern)
  • Metastatic disease (renal cell carcinoma)
  • Primary skin tumors with follicular differentiation
  • Sebaceous differentiation, or sweat gland differentiation
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