Skin nonmelanocytic tumor
Adnexal tumors
Sweat gland derived (apocrine & eccrine glands)

Topic Completed: 1 June 2012

Minor changes: 15 January 2021

Copyright: 2002-2021,, Inc.

PubMed Search: Eccrine acrospiroma [title]

Christopher S. Hale, M.D.
Page views in 2020: 28,973
Page views in 2021 to date: 5,974
Cite this page: Hale C. Hidradenoma. website. Accessed March 5th, 2021.
Definition / general
  • Arises from sweat gland distal excretory duct, usually solitary, on the scalp, axillae
  • Synonyms: Nodular hidradenoma, eccrine acrospiroma
Gross description
  • Nodules with cystic foci high in dermis
Microscopic (histologic) description
  • Nests / lobules of cells resembling eccrine poroma with either clear cytoplasm or prominent squamous metaplasia
  • May have marked vascularity
  • Small and large lumina are lined by cuboidal ductal cells or columnar secretory cells
  • Cystic spaces may be due to degeneration of tumor cells
Microscopic (histologic) images

Contributed by Angel Fernandez-Flores, M.D., Ph.D.

Contributed by Mark R. Wick, M.D.

Breast skin

Positive stains
Differential diagnosis
  • Apocrine mixed tumor
  • Glomus tumor (different staining pattern)
  • Metastatic disease (renal cell carcinoma)
  • Primary skin tumors with follicular differentiation
  • Sebaceous differentiation, or sweat gland differentiation
Back to top
Image 01 Image 02