Skin nonmelanocytic tumor
Adnexal tumors
Sebaceous glands
Sebaceous carcinoma


Topic Completed: 1 June 2012

Minor changes: 4 January 2021

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PubMed Search: Sebaceous carcinoma [title] skin

Christopher S. Hale, M.D.
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Cite this page: Hale C. Sebaceous carcinoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/skintumornonmelanocyticsebaceouscarcinoma.html. Accessed January 22nd, 2021.
Definition / general
  • Rare
  • Periocular vs. extraocular types
  • Tumors of eyelids, caruncles and orbit are more aggressive than extraocular tumors
  • May follow radiation therapy
  • Also associated with Muir-Torre syndrome (multiple cutaneous tumors with sebaceous and hair follicle differentiation and multiple internal malignancies; tumors have cystic growth pattern, Histopathology 2010;56:133)
Prognostic factors
  • Poor prognostic factors: necrosis
Case reports
Clinical images

Images hosted on other servers:

Presenting as BCC

On the superior right eyelid

Microscopic (histologic) description
  • Sebaceous differentiation, but also marked atypia, mitotic figures, invasion
Microscopic (histologic) images

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Contributed by Mark R. Wick, M.D.

Grade 1

Grade 2

Grade 3

In situ, pilar unit

Squamoid variant

BerEP4+


Pagetoid

Neuroendocrine-like

CK7+

EMA+


Adipophilin+

Various images



Various images



Images hosted on other servers:

4x

10x

20x


40x

Full-thickness wedge resection

Scattered pleomorphic cells

Involving the lower eyelid

Positive stains
Negative stains
Differential diagnosis
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