Testis & epididymis
Nonneoplastic lesions
Proliferative funiculitis

Topic Completed: 1 April 2014

Minor changes: 10 September 2020

Copyright: 2002-2020, PathologyOutlines.com, Inc.

PubMed Search: Proliferative funiculitis

See also: Nodular fasciitis

Rafael Jimenez, M.D.
Jerad M. Gardner, M.D.
Page views in 2019: 676
Page views in 2020 to date: 500
Cite this page: Stuart LN, Jimenez R, Gardner JM. Proliferative funiculitis. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/softtissuepf.html. Accessed September 30th, 2020.
Definition / general
  • Also known as pseudosarcomatous myofibroblastic proliferation of spermatic cord
  • Some studies mention relationship to: inflammatory myofibroblastic tumor, inflammatory pseudotumor, atypical myofibroblastic tumor, pseudosarcoma (Urology 2009;73:1423)
  • These terms are often used inappropriately in literature and may not truly be related to proliferative funiculitis
  • Older men (ages 52 - 76 years)
  • May be due to ischemia, torsion or extension of vasitis
Clinical features
  • Normal levels of α-fetoprotein, β-human chorionic gonadotropin
Radiology description
Prognostic factors
  • Can recur locally; excellent prognosis when resected with negative margins
  • Surgical resection
Gross description
Gross images

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Tumor in undescended testis

Inguinal tumor

Microscopic (histologic) description
  • Infiltrative spindle cell proliferation within a myxoid or loose collagenous stroma
  • Nuclei are oval to fusiform
  • Basophilic nucleoli may be present
  • Mixed inflammatory infiltrate mainly composed of plasma cells and lymphocytes
  • May contain malignant appearing glandular structures composed of keratin+ mesothelial cells (Int J Surg Pathol 2008;16:48), rarely has proliferation of mast cells (Pathol Int 2003;53:897)
Microscopic (histologic) images

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Spindle cell proliferation

Positive stains
Negative stains
Differential diagnosis
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