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Esophagus
Premalignant lesions
Barrett's esophagus (BE)

Reviewer: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 3 July 2013, last major update April 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

Definition
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Terminology
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Pathophysiology
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Etiology
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Clinical features
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Diagrams
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Topographic distribution

Patterns

Esophageal biopsy protocol


Diagnosis
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Laboratory
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Treatment
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Clinical images
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Endoscopy: mucosal erythema of lower esophagus

Endoscopic appearance of hiatus hernia mimicking Barrett's esophagus

Normal and Barrett's

Gross description
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Gross images
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Tongues of tan-orange mucosa

Adenocarcinoma in Barrett's esophagus #1

#2

#3

Micro description
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Micro images
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Histology of Barrett's esophagus

Tongue of Barrett's mucosa

With mucosal erosion and bizarre stromal cells

Exuberant granulation tissue

Small island of squamous epithelium

Villous pattern seen in areas of erosion with regeneration


Barrett's: various images

Barrett's

Intestinalized epithelium

Dysplastic foveolar epithelium


Mucin stains of Barrett's mucosa

Gastroesophageal junction: H&E and Alcian Blue

Alcian Blue


Classic staining pattern: CK7 & CK20

Classic staining pattern: CK7 & CK20

Nonclassic staining pattern


H&E and CDX2+

Various stains #1

#2

#3



Contributed by Dr. Mark R. Wick:

Low grade dysplasia

Metaplasia, high grade dysplasia

Metaplastic

Metaplasia with dysplasia


Adenocarcinoma associated with Barrett's #1

#2

#3

#4



Positive stains
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Electron microscopy description
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Differential diagnosis
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Additional references
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End of Esophagus > Premalignant lesions > Barrett's esophagus (BE)


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