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Esophagus
Other malignancies
Gastrointestinal stromal tumor (GIST)

Reviewer: Feriyl Bhaijee, M.D. (see Reviewers page)
Editor: Israh Akhtar, M.D.
Revised: 3 September 2013, last major update August 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
PubMed Search: GIST esophagus

General
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Terminology
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Epidemiology
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Sites
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Etiology
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Clinical features
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Diagnosis
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Radiology
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Radiology images
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40 year old man with dysphagia

Enhancing chest CT

CT scan shows well circumscribed tumor

Prognostic factors
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Risk category Tumor size Mitotic rate/50HPF
Low < 5 cm < 5
Intermediate < 5 cm 6-10
Intermediate 5-10 cm < 5
High > 5 cm > 5
High > 10 cm Any mitotic rate
High Any size > 10

Case reports
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Treatment
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Clinical images
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Endoscopic images

Gross description
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Gross images
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19 cm tumor with cystic degeneration and necrosis

Multinodular, well circumscribed mass in posterior mediastinum

Micro description
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Micro images
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Dense cellularity, mixture of epithelioid and spindled areas

Intramural nodule and fascicular arrangement of spindle cells


H&E

Spindle cell proliferation

Moderate atypia, occasional mitotic figures

KIT


KIT/CD117

CD117 and desmin

CD117, CD34, SMA, S100

Cytology description
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Cytology images
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Spindle cells with high cellularity

Epithelioid cells with round nuclei

Clusters of atypical epithelioid and spindle cells

Positive stains
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Negative stains
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Electron microscopy description
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Electron microscopy images
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Ultrastructural demonstration of cytoplasmic vesicles in high risk GIST

Molecular / cytogenetics description
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Differential diagnosis
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Additional references
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End of Esophagus > Other malignancies > Gastrointestinal stromal tumor (GIST)


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