Kidney tumor
Adult renal carcinoma
Solid growth pattern of papillary renal cell carcinoma (PRCC)

Author: Nicole K. Andeen, M.D.
Editor: Maria Tretiakova, M.D., Ph.D.

Revised: 25 April 2018, last major update February 2018

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Solid papillary renal cell carcinoma

See Also: Papillary type, renal cell carcinoma, Type 1, Type 2
Cite this page: Andeen, N. K. Solid growth pattern of papillary renal cell carcinoma . PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/kidneytumormalignantrccpapsldvar.html. Accessed August 15th, 2018.
Definition / general
Essential features
  • Similar to type 1 PRCC by morphology, immunohistochemistry and cytogenetics but lacks true papillae
Epidemiology
  • M:F ratio is 1.7:1
  • Comprises less than 3% of all PRCCs
Sites
  • Kidney
Case reports
Treatment
Gross description
Gross images

Images hosted on other servers:

Solid, firm, tan tumor protruding from the renal cortex

Microscopic (histologic) description
  • Solid sheets of cells, often with distinct micronodules resembling abortive papillae or glomeruloid bodies, surrounded by a pseudocapsule (Histopathology 2013;62:941)
  • Resembles type 1 PRCC immunophenotypically and genetically but lacks true papillae containing fibrovascular cores (Am J Surg Pathol 1997;21:1203)
  • Cells have scant to abundant clear, basophilic or eosinophilic cytoplasm
  • Nuclei may be low or high grade, may have nucleoli or nuclear grooves
  • May have compact areas of low grade spindle cells lining thin, angulated tubules resembling mucinous tubular and spindle cell carcinoma but no mucinous stroma (Am J Surg Pathol 2008;32:1353)
  • May have foamy macrophages, psammoma bodies (Histopathology 2013;62:941)
Microscopic (histologic) images

Images hosted on PathOut server:

Images contributed by Nicole K. Andeen, M.D. and Maria Tretiakova, M.D., Ph.D.

Solid PRCC



Images hosted on other servers:

Various images

Positive stains
Negative stains
Molecular / cytogenetics description
  • Trisomy 7 and 17, similar to type 1 PRCC
Differential diagnosis
  • Metanephric adenoma: expresses CD57 and WT1 and is negative for CK7 and AMACR; solid PRCC has opposite staining profile
  • Mucinous tubular and spindle cell carcinoma: spindle cell areas are uniformly low grade, no mucinous stroma, no +7 or +17
  • PRCC, type 1 or type 2: both have true papillae, which the solid growth pattern lacks
  • Synovial sarcoma: may be biphasic (epithelial and mesenchymal components) or monophasic; positive for TLE1 by immunohistochemistry and SYT gene rearrangement
Board review question #1
Papillary RCC, solid growth pattern:

  1. Has a poor clinical outcome
  2. Is a type 2 PRCC with solid growth pattern
  3. Is immunohistochemically and cytogenetically distinct from both type 1 and type 2 PRCC
  4. Shares morphologic, immunohistochemical and cytogenetic features with type 1 PRCC but lacks true papillae
Board review answer #1
D. Shares morphologic, immunohistochemical and cytogenetic features with type 1 PRCC but lacks true papillae