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Lymphoma - B cell neoplasms

B cell lymphoma subtypes

Age-related EBV-associated B-cell lymphoproliferative disorders


Reviewer: Nikhil Sangle, M.D., University of Utah and ARUP Laboratories (see Reviewers page)
Revised: 23 February 2011, last major update February 2011
Copyright: (c) 2001-2011, PathologyOutlines.com, Inc.

Definition
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● Clonal proliferation of EBV positive lymphocytes in patients > 50 years, with no known immunodeficiency state or prior lymphoma, and excluding patients with well-defined EBV+ disorders such as primary effusion lymphoma

Clinical features
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● Extranodal (skin, lung, tonsil and GI tract) involvement common
● Aggressive disease, with median survival of 2 years (Clin Cancer Res 2007;13:5124)
● Poorer prognosis if age > 70 years or B symptoms

Micro description
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● Effaced lymph node architecture due to large cells (immunoblasts/centroblasts) with admixed reactive small lymphocytes, plasma cells and histiocytes

Micro images
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Various images

Positive stains
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● Large cells are positive for CD20, CD79a, monoclonal light chain, IRF4/MUM1

Negative stains
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● CD10 and bcl6 are often negative

Molecular
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● Clonal population by molecular techniques, in contrast to infectious mononucleosis

End of Lymphoma - B cell neoplasms > B cell lymphoma subtypes > Age-related EBV-associated B-cell lymphoproliferative disorders


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