Lymphoma - B cell neoplasms
B cell lymphoma subtypes
Age-related EBV-associated B-cell lymphoproliferative disorders

Author: Nikhil Sangle, M.D. (see Authors page)

Revised: 15 November 2016, last major update February 2011

Copyright: (c) 2001-2016, PathologyOutlines.com, Inc.

Cite this page: Lymphoma - B cell neoplasms - Age-related EBV-associated B-cell lymphoproliferative disorders. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/lymphomadiffuseEBV.html. Accessed December 6th, 2016.
Definition / General
  • Clonal proliferation of EBV positive lymphocytes in patients > 50 years, with no known immunodeficiency state or prior lymphoma, and excluding patients with well-defined EBV+ disorders such as primary effusion lymphoma
Clinical Features
  • Extranodal (skin, lung, tonsil and GI tract) involvement common
  • Aggressive disease, with median survival of 2 years (Clin Cancer Res 2007;13:5124)
  • Poorer prognosis if age > 70 years or B symptoms
Micro Description
  • Effaced lymph node architecture due to large cells (immunoblasts/centroblasts) with admixed reactive small lymphocytes, plasma cells and histiocytes
Positive Stains
Negative Stains
Molecular / Cytogenetics Description
  • Clonal population by molecular techniques, in contrast to infectious mononucleosis
Lymphoma - B cell neoplasms - Age-related EBV-associated B-cell lymphoproliferative disorders



Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Lymphoma - B cell neoplasms

B cell lymphoma subtypes

Age-related EBV-associated B-cell lymphoproliferative disorders


Reviewer: Nikhil Sangle, M.D., University of Utah and ARUP Laboratories (see Reviewers page)
Revised: 23 February 2011, last major update February 2011
Copyright: (c) 2001-2011, PathologyOutlines.com, Inc.

Definition
=========================================================================

● Clonal proliferation of EBV positive lymphocytes in patients > 50 years, with no known immunodeficiency state or prior lymphoma, and excluding patients with well-defined EBV+ disorders such as primary effusion lymphoma

Clinical features
=========================================================================

● Extranodal (skin, lung, tonsil and GI tract) involvement common
● Aggressive disease, with median survival of 2 years (Clin Cancer Res 2007;13:5124)
● Poorer prognosis if age > 70 years or B symptoms

Micro description
=========================================================================

● Effaced lymph node architecture due to large cells (immunoblasts/centroblasts) with admixed reactive small lymphocytes, plasma cells and histiocytes

Micro images
=========================================================================



Various images

Positive stains
=========================================================================

● Large cells are positive for CD20, CD79a, monoclonal light chain, IRF4/MUM1

Negative stains
=========================================================================

● CD10 and bcl6 are often negative

Molecular
=========================================================================

● Clonal population by molecular techniques, in contrast to infectious mononucleosis

End of Lymphoma - B cell neoplasms > B cell lymphoma subtypes > Age-related EBV-associated B-cell lymphoproliferative disorders


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at [email protected] with any questions (click here for other contact information).