Lymphoma and plasma cell neoplasms
B cell lymphoma subtypes
EBV+ diffuse large B cell lymphoma, NOS

Topic Completed: 1 February 2011

Minor changes: 27 May 2020

Copyright: 2001-2020,, Inc.

PubMed Search: EBV+ diffuse large B cell lymphoma

Nikhil Sangle, M.D.
Page views in 2019: 712
Page views in 2020 to date: 379
Cite this page: Sangle N. EBV+ diffuse large B cell lymphoma, NOS. website. Accessed May 30th, 2020.
Definition / general
  • Clonal proliferation of EBV positive lymphocytes in patients > 50 years, with no known immunodeficiency state or prior lymphoma, and excluding patients with well defined EBV+ disorders such as primary effusion lymphoma
Clinical features
  • Extranodal (skin, lung, tonsil and GI tract) involvement common
  • Aggressive disease, with median survival of 2 years (Clin Cancer Res 2007;13:5124)
  • Poorer prognosis if age > 70 years or B symptoms
Microscopic (histologic) description
  • Effaced lymph node architecture due to large cells (immunoblasts / centroblasts) with admixed reactive small lymphocytes, plasma cells and histiocytes
Positive stains
Negative stains
Molecular / cytogenetics description
  • Clonal population by molecular techniques, in contrast to infectious mononucleosis
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