Lymphoma and plasma cell neoplasms
B cell lymphoma subtypes
Age related EBV associated B cell lymphoproliferative disorders

Author: Nikhil Sangle, M.D. (see Authors page)

Revised: 3 April 2017, last major update February 2011

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PubMed Search: age related EBV associated B cell lymphoproliferative disorders

Cite this page: Age related EBV associated B cell lymphoproliferative disorders. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/lymphomadiffuseEBV.html. Accessed June 27th, 2017.
Definition / general
  • Clonal proliferation of EBV positive lymphocytes in patients > 50 years, with no known immunodeficiency state or prior lymphoma, and excluding patients with well defined EBV+ disorders such as primary effusion lymphoma
Clinical features
  • Extranodal (skin, lung, tonsil and GI tract) involvement common
  • Aggressive disease, with median survival of 2 years (Clin Cancer Res 2007;13:5124)
  • Poorer prognosis if age > 70 years or B symptoms
Microscopic (histologic) description
  • Effaced lymph node architecture due to large cells (immunoblasts / centroblasts) with admixed reactive small lymphocytes, plasma cells and histiocytes
Positive stains
Negative stains
Molecular / cytogenetics description
  • Clonal population by molecular techniques, in contrast to infectious mononucleosis