Lymphoma and plasma cell neoplasms
B cell lymphoma subtypes
Age related EBV associated B cell lymphoproliferative disorders



Topic Completed: 1 February 2011

Revised: 6 February 2019

Copyright: 2001-2017, PathologyOutlines.com, Inc.

PubMed Search: age related EBV associated B cell lymphoproliferative disorders


Nikhil Sangle, M.D.
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Cite this page: Sangle N. Age related EBV associated B cell lymphoproliferative disorders. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/lymphomadiffuseEBV.html. Accessed December 10th, 2019.
Definition / general
  • Clonal proliferation of EBV positive lymphocytes in patients > 50 years, with no known immunodeficiency state or prior lymphoma, and excluding patients with well defined EBV+ disorders such as primary effusion lymphoma
Clinical features
  • Extranodal (skin, lung, tonsil and GI tract) involvement common
  • Aggressive disease, with median survival of 2 years (Clin Cancer Res 2007;13:5124)
  • Poorer prognosis if age > 70 years or B symptoms
Microscopic (histologic) description
  • Effaced lymph node architecture due to large cells (immunoblasts / centroblasts) with admixed reactive small lymphocytes, plasma cells and histiocytes
Positive stains
Negative stains
Molecular / cytogenetics description
  • Clonal population by molecular techniques, in contrast to infectious mononucleosis
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