Lymphoma & related disorders
Mature B cell neoplasms
Large B cell lymphomas-special subtypes
EBV+
Author: Nikhil Sangle, M.D.
Topic Completed: 1 February 2011
Minor changes: 11 January 2021
Copyright: 2001-2021, PathologyOutlines.com, Inc.
PubMed Search: EBV+ diffuse large B cell lymphoma
Table of Contents
Definition / general | Clinical features | Microscopic (histologic) description | Positive stains | Negative stains | Molecular / cytogenetics descriptionCite this page: Sangle N. EBV+. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/lymphomadiffuseEBV.html. Accessed January 22nd, 2021.
Definition / general
- Clonal proliferation of EBV positive lymphocytes in patients > 50 years, with no known immunodeficiency state or prior lymphoma, and excluding patients with well defined EBV+ disorders such as primary effusion lymphoma
Clinical features
- Extranodal (skin, lung, tonsil and GI tract) involvement common
- Aggressive disease, with median survival of 2 years (Clin Cancer Res 2007;13:5124)
- Poorer prognosis if age > 70 years or B symptoms
Microscopic (histologic) description
- Effaced lymph node architecture due to large cells (immunoblasts / centroblasts) with admixed reactive small lymphocytes, plasma cells and histiocytes
Positive stains
- Large cells are positive for CD20, CD79a, monoclonal light chain, IRF4 / MUM1
Molecular / cytogenetics description
- Clonal population by molecular techniques, in contrast to infectious mononucleosis
