Mediastinum
Thymic carcinoma
NUT midline carcinomas (NMCs)




Topic Completed: 1 December 2012

Revised: 14 February 2019

Copyright: 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: NUT midline carcinoma mediastinum

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Cite this page: Gulwani H. NUT midline carcinomas (NMCs). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/mediastinumNMC.html. Accessed March 23rd, 2019.
Definition / general
  • Aggressive subset of squamous cell carcinoma defined by rearrangement of NUT (NUclear protein in Testis) gene on #15 to other genes, usually BRD4 on #19 (Head Neck Pathol 2011;5:31)
  • First described in 1991 (Cancer Res 1991;51:3327)
  • Originally thought to be limited to mediastinum but 35% occur in head and neck
  • Highly aggressive, with median survival of 7 months due to ineffective chemotherapy
  • Must rule out for any poorly differentiated epithelioid mediastinal tumor, regardless of age
Sites
  • Head, neck and mediastinum of younger individuals
Microscopic (histologic) description
  • Undifferentiated epithelioid or round cell malignant cells, variable focal squamous differentiation
Microscopic (histologic) images

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Head and neck

Various images

Cytology images

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Head and neck

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