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Skin - Nonmelanocytic tumors

Other tumors of skin


Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 14 August 2012, last major update August 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

See also Soft Tissue - cellular angiofibroma


● Also called fibrous papule of face
● Perifollicular fibroma may be variant
● Usually on nose of middle-aged
● Also corona of penis and oral cavity
● Multiple angiofibromas associated with tuberous sclerosis, Birt-Hogg-Dubé syndrome, and multiple endocrine neoplasia type 1 (MEN1)
● May be hamartoma composed of perifollicular or interfollicular connective tissue and a hair follicular epithelial component, which may be caused by an abnormal functioning of the hair follicle bulge cells (J Cutan Pathol 2009;36:943)
● May be derived from dermal dendrocytes

Gross description

● Solitary, dome-shaped, firm lesion

Micro description

● Increased blood vessels with dilated lumina, fibroblastic stroma containing stellate or multinucleated cells similar to pleomorphic fibroma
● Numerous hair follicles surrounded by collagen fibers
● Normal or slightly acanthotic epidermis with vacuolated clear cells

Micro images

30 year old man with nose lesion, images contributed by Drs. Asmaa Gaber Abdou and Nancy Asaad, Menofiya University, Egypt

Differential diagnosis

● Involuting nevus: no stellate cells or cellular stroma
● Telangiectasia: no stellate cells or cellular stroma
● Angioma: no stellate cells or cellular stroma

End of Skin - Nonmelanocytic tumors > Other tumors of skin > Angiofibroma

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