Skin tumor - Nonmelanocytic

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Skin - Nonmelanocytic tumors

Other tumors of skin

Angiofibroma

Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 14 August 2012, last major update August 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

See also Soft Tissue - cellular angiofibroma

General
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● Also called fibrous papule of face
● Perifollicular fibroma may be variant
● Usually on nose of middle-aged
● Also corona of penis and oral cavity
● Multiple angiofibromas associated with tuberous sclerosis, Birt-Hogg-Dubé syndrome, and multiple endocrine neoplasia type 1 (MEN1)
● May be hamartoma composed of perifollicular or interfollicular connective tissue and a hair follicular epithelial component, which may be caused by an abnormal functioning of the hair follicle bulge cells (J Cutan Pathol 2009;36:943)
● May be derived from dermal dendrocytes

Gross description
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● Solitary, dome-shaped, firm lesion

Micro description
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● Increased blood vessels with dilated lumina, fibroblastic stroma containing stellate or multinucleated cells similar to pleomorphic fibroma
● Numerous hair follicles surrounded by collagen fibers
● Normal or slightly acanthotic epidermis with vacuolated clear cells

Micro images
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30 year old man with nose lesion, images contributed by Drs. Asmaa Gaber Abdou and Nancy Asaad, Menofiya University, Egypt

Differential diagnosis
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● Involuting nevus: no stellate cells or cellular stroma
● Telangiectasia: no stellate cells or cellular stroma
● Angioma: no stellate cells or cellular stroma

End of Skin - Nonmelanocytic tumors > Other tumors of skin > Angiofibroma

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