Soft tissue
Adipose tissue
Pleomorphic lipoma / spindle cell lipoma - General

Author: Vijay Shankar, M.D. (see Authors page)

Revised: 4 August 2016, last major update August 2012

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PubMed Search: Pleomorphic lipoma / spindle cell lipoma

See also: pleomorphic lipoma, spindle cell lipoma

Cite this page: Pleomorphic lipoma / spindle cell lipoma - General. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/softtissueadiposepleomorphicgeneral.html. Accessed August 18th, 2017.
Definition / general
  • Subcutaneous tumor of back, shoulder or posterior neck with mature adipocytes, bland spindle cells, floret cells and collagen (Stanford University)
Epidemiology
  • Pleomorphic lipoma and spindle cell lipoma represent a continuum of benign tumors - most tumors show some features of both
  • 70% occur in subcutaneous tissue of shoulder, back and posterior neck
  • 90% men
  • Usually ages 45 - 65 years
  • Usually relatively superficial
  • If deep, some suggest calling well differentiated liposarcoma
Treatment
  • Excision
  • Only rare local recurrences, no metastases
Gross description
  • Usually 3 - 5 cm, well circumscribed, yellow-gray-white, firmer than classic lipoma
Molecular / cytogenetics description
  • 16q or 13q abnormalities in 70%
  • Frequently hypodiploid