Soft tissue
Adipose tissue
Pleomorphic lipoma / spindle cell lipoma - General

Topic Completed: 1 August 2012

Revised: 20 March 2019

Copyright: 2002-2018,, Inc.

PubMed Search: Pleomorphic lipoma / spindle cell lipoma

See also: pleomorphic lipoma, spindle cell lipoma

Vijay Shankar, M.D.
Page views in 2018: 3,167
Page views in 2019 to date: 2,320
Cite this page: Shankar V. Pleomorphic lipoma / spindle cell lipoma - General. website. Accessed September 22nd, 2019.
Definition / general
  • Subcutaneous tumor of back, shoulder or posterior neck with mature adipocytes, bland spindle cells, floret cells and collagen (Stanford University)
  • Pleomorphic lipoma and spindle cell lipoma represent a continuum of benign tumors - most tumors show some features of both
  • 70% occur in subcutaneous tissue of shoulder, back and posterior neck
  • 90% men
  • Usually ages 45 - 65 years
  • Usually relatively superficial
  • If deep, some suggest calling well differentiated liposarcoma
  • Excision
  • Only rare local recurrences, no metastases
Gross description
  • Usually 3 - 5 cm, well circumscribed, yellow-gray-white, firmer than classic lipoma
Molecular / cytogenetics description
  • 16q or 13q abnormalities in 70%
  • Frequently hypodiploid
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