Benign / nonneoplastic epithelial lesions


Topic Completed: 1 May 2007

Minor changes: 11 July 2021

Copyright: 2007-2021, PathologyOutlines.com, Inc.

PubMed Search: Endometriosis cervix

See also Ovary topic
See subtype below: Stromal endometriosis

Branko Perunovic, D.M.
Marilin Rosa, M.D.
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Cite this page: Perunovic B, Rosa M. Endometriosis. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cervixendometriosis.html. Accessed October 15th, 2021.
Definition / general
  • May cause abnormal uterine bleeding, postcoital bleeding
  • Mean age 37 years, range 20 to 51 years
  • Superficial endometriosis may be due to mechanical disruption of endometrium after D & C or cone biopsy
Case reports
Gross description
  • Red / blue nodules
Microscopic (histologic) description
  • Similar to endometriosis elsewhere
  • Two of three present - endometrial glands with basal nuclei, spindled stroma, hemorrhage
  • Usually involves superficial third of cervical wall, not deep wall
  • Glands are evenly spaced and without atypia, are surrounded by stroma at least focally
  • Inflammation and hemorrhage may obscure endometrial storm
  • May have prominent mitotic activity
  • No thick collagen bundles
Microscopic (histologic) images

AFIP images


Cytology description
  • Endometrial type cells in solid and cohesive clusters (may be tridimensional) with crowded, overlapping glandular groups, loss of cellular polarity and a frequent ragged "feathered" edge appearance with protruding nuclei (Diagn Cytopathol 2004;30:88)
  • Also hemosiderin laden macrophages and sometimes spindle stromal cells
  • No pseudostratified cell strips (Diagn Cytopathol 1999;21:188)
Positive stains
Additional references

Stromal endometriosis
Definition / general
  • Endometriotic stroma only with no/rare glands
  • Mean age 43 years, range 29 to 64 years
Microscopic (histologic) description
  • Well circumscribed foci within cervical superficial stroma containing endometrial stromal cells, small blood vessels, extravasated RBCs
  • Usually no endometrial type glands
Additional references
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