Benign / nonneoplastic epithelial lesions

Mesonephric hyperplasia

Last author update: 1 April 2017
Last staff update: 15 December 2022

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PubMed Search: Mesonephric hyperplasia cervix

Carlos Parra-Herran, M.D.
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Cite this page: Parra-Herran C. Mesonephric hyperplasia. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cervixmesonephrichyper.html. Accessed February 6th, 2023.
Definition / general
Case reports
Microscopic (histologic) description
  • Mesonephric duct remnants appear as groups of round glands and tubules, lined by simple flat to low cuboidal epithelium
  • Glandular lumen is usually filled with a dense eosinophilic PAS positive, diastase resistant material; mucinous or ciliated cells are not identified
  • Hyperplasia of mesonephric ducts is characterized by a glandular population similar to mesonephric remnants but larger, more irregular and haphazardly distributed with increase in lobule size and extensive involvement of the cervix
  • Either lobular, diffuse (bland glands, no stromal reaction) or ductal patterns (large, dilated or irregular ducts in wall of cervix with micropapillary budding of pseudostratified epithelial cells without atypia); lobular is the most frequent
  • Small round mesonephric tubules are often deep within cervical wall and extend to cervical surface
  • May appear infiltrative
  • No back to back glandular crowding, no nuclear atypia, no angiolymphatic invasion, no perineural invasion
Microscopic (histologic) images

Contributed by Michela Campora, M.D., Carlos Parra-Herran, M.D. and AFIP
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Mesonephric hyperplasia

Marked tubular proliferation

More nuclear variation

Bland glands deep in cervical stroma

Clusters of mesonephric tubules

Mesonephric remnants

Cuboidal cells

Focal squamous metaplasia

Cytology description
Positive stains
Negative stains
Differential diagnosis
Additional references
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