Benign / nonneoplastic epithelial lesions

Mesonephric hyperplasia

Topic Completed: 1 April 2017

Minor changes: 30 November 2020

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PubMed Search: Mesonephric hyperplasia cervix

Carlos Parra-Herran, M.D.
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Cite this page: Parra-Herran C. Mesonephric hyperplasia. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/cervixmesonephrichyper.html. Accessed December 2nd, 2021.
Definition / general
Microscopic (histologic) description
  • Mesonephric duct remnants appear as groups of round glands and tubules, lined by simple flat to low cuboidal epithelium
  • Glandular lumen is usually filled with a dense eosinophilic PAS positive, diastase resistant material; mucinous or ciliated cells are not identified
  • Hyperplasia of mesonephric ducts is characterized by a glandular population similar to mesonephric remnants but larger, more irregular and haphazardly distributed with increase in lobule size and extensive involvement of the cervix
  • Either lobular, diffuse (bland glands, no stromal reaction) or ductal patterns (large, dilated or irregular ducts in wall of cervix with micropapillary budding of pseudostratified epithelial cells without atypia); lobular is the most frequent
  • Small round mesonephric tubules are often deep within cervical wall and extend to cervical surface
  • May appear infiltrative
  • No back to back glandular crowding, no nuclear atypia, no angiolymphatic invasion, no perineural invasion
Microscopic (histologic) images

Contributed by Michela Campora, M.D.
Missing Image Missing Image Missing Image Missing Image

Mesonephric hyperplasia

AFIP images

Marked tubular
proliferation but with
lobular architecture

More nuclear
variation than in
mesonephric rests

Bland glands deep in cervical stroma

Contributed by Carlos Parra-Herran, M.D.
Cytology description
Positive stains
Negative stains
Differential diagnosis
Additional references
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