Sex cord stromal tumors

Leydig cell tumor

Last author update: 1 December 2012
Last staff update: 30 May 2023 (update in progress)

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PubMed search: Ovarian Leydig cell tumor

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Cite this page: Ehdaivand S. Leydig cell tumor. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/ovarytumorleydig.html. Accessed May 30th, 2023.
Definition / general
  • Rare, derived from hilar cells
  • Almost always benign
  • Call a nonhilar Leydig cell tumor if it occurs in ovarian cortical stroma
  • Symptoms: virilization, elevated 17-ketosteroid excretion and unresponsive to cortisol suppression
  • Excision
Gross description
  • Unilateral
Gross images

AFIP images

Red-brown mass

Brown-black nodule

Microscopic (histologic) description
  • Large lipid laden cells with distinct borders; Reinke crystals common
Microscopic (histologic) images

AFIP images

Crystals of Reinke

Separated cellular areas

Prominent fibrous stroma

Fibrinoid replacement

Abundant, pale, vacuolated cytoplasm

Enlarged, hyperchromatic, bizarre nuclei

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