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General
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Terminology
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Clinical features
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Case reports
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Treatment
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Clinical images
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10 cm mass

Gross description
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Micro description
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Micro images
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AFIP images:

Ribbon growth pattern with spindled cells

Cells often have argyrophilic Grimeliius+ granules, tumor is immunoreactive for chromogranin



Contributed by Dr. Semir Vranic, Sarajevo:

Focal mucin production

Chromogranin expression

Synaptophysin expression

Estrogen receptor

HER2 protein

Neuroendocrine carcinoma of the breast


Cells in small and large nests

No pleomorphism

Hint of lumen

Well differentiated tumor with alveolar growth pattern


Fig 2: H&E, chromogranin and synaptophysin

Chromogranin immunoreactivity

Various markers (Fig G, H, I)

(Fig A-D, H-I)

Carcinomatous lymphangitis

Synaptophysin+

Cytology description
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Positive stains
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Electron microscopy description
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Electron microscopy images
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Dense core granules throughout the cytoplasm, but increased at cell membrane

Dense core granules measure 270-430 nm cluster near cell membrane

Differential diagnosis
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Additional references
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End of Breast malignant, males, children > Carcinoma subtypes > Neuroendocrine carcinoma - general



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