Home   Chapter Home   Jobs   Conferences   Fellowships   Books


Skin - Nonmelanocytic tumors

Adnexal tumors - eccrine sweat glands

Aggressive digital papillary adenoma

Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 23 June 2012, last major update June 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.


● Also called digital papillary eccrine adenoma
● Usually digits
● Recurs locally
● Histologic criteria not reliable for distinguishing from digital papillary adenocarcinoma (Modern Pathol 2006;19:S93)
● Malignant counterpart has poor glandular differentiation, necrosis, atypia, invasion
● Metastasizes to lung in many cases

Case reports

● 78 year old Japanese woman with tumor on forearm (J Cutan Pathol 1998;25:59)

Micro description

● Tubuloalveolar and ductal structures
● Also areas of papillary projections protruding into lumina (may resemble breast carcinoma)

Micro images

Fairly well-circumscribed lesion within deep dermis of branching glandular spaces with papillary projections in loose fibrous stroma; overlying epidermis is uninvolved

Positive stains

● Outer cell layer immunoreactive for alpha-SMA, K14
● Inner cell layer immunoreactive for K8 (J Cutan Pathol 1998;25:59)

Differential diagnosis

● Digital papillary adenocarcinoma
● Metastatic adenocarcinoma
● Microcystic adnexal carcinoma
● Hidradenoma papilliferum
● Syringocystadenoma papilliferum
● Nipple adenoma

End of Skin - Nonmelanocytic tumors > Adnexal tumors - eccrine sweat glands > Aggressive digital papillary adenoma

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at [email protected] with any questions (click here for other contact information).