Skin tumor - Nonmelanocytic - Aggressive digital papillary adenoma

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Skin - Nonmelanocytic tumors

Adnexal tumors - eccrine sweat glands

Aggressive digital papillary adenoma

Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 23 June 2012, last major update June 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
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● Also called digital papillary eccrine adenoma
● Usually digits
● Recurs locally
● Histologic criteria not reliable for distinguishing from digital papillary adenocarcinoma (Modern Pathol 2006;19:S93)
● Malignant counterpart has poor glandular differentiation, necrosis, atypia, invasion
● Metastasizes to lung in many cases

Case reports
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● 78 year old Japanese woman with tumor on forearm (J Cutan Pathol 1998;25:59)

Micro description
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● Tubuloalveolar and ductal structures
● Also areas of papillary projections protruding into lumina (may resemble breast carcinoma)

Micro images
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Fairly well-circumscribed lesion within deep dermis of branching glandular spaces with papillary projections in loose fibrous stroma; overlying epidermis is uninvolved

Positive stains
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● Outer cell layer immunoreactive for alpha-SMA, K14
● Inner cell layer immunoreactive for K8 (J Cutan Pathol 1998;25:59)

Differential diagnosis
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● Digital papillary adenocarcinoma
● Metastatic adenocarcinoma
● Microcystic adnexal carcinoma
● Hidradenoma papilliferum
● Syringocystadenoma papilliferum
● Nipple adenoma

End of Skin - Nonmelanocytic tumors > Adnexal tumors - eccrine sweat glands > Aggressive digital papillary adenoma

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