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See subtype below: Indeterminate lesionsMyxoid variantSarcomas

General
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Case reports
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Treatment
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Clinical images
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Papulonodular thigh lesions

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Before and after Imatinib treatment

Gross description
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Micro description
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Micro images
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Breast skin, courtesy of Dr. Mark R. Wick

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Breast skin, CD34, courtesy of Dr. Mark R. Wick

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Fine strands of collagen are present

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Infiltration of fat causes tumor cells to surround fat cells

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DFSP with diminished storiform pattern but CD34+ (not shown)

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Pigmented cells are not common

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Variants: with fibrosarcomatous component, myxoid, pigmented

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Small uniform cells radiating like pinwheels from central area that often has a blood vessel is characteristic

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Uniform cells with no significant pleomorphism, minimal intercellular collagen, no/rare foam cells or giant cells, which are characteristic of benign fibrous histiocytoma

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Residual fat cells are in linear arrangement resembling a string of pearls, which is characteristic of DFSP but not benign fibrous histiocytoma

Cytology description
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Positive stains
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Negative stains
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Electron microscopy description
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Molecular / cytogenetics description
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Differential diagnosis
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Indeterminate lesions between DFSP and dermatofibroma

General
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Myxoid variant of DFSP

General
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Case reports
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Treatment
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Gross description
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Micro description
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Micro images
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Case of the week

Virtual slides
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Myxoid DFSP

Positive stains
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Negative stains
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Differential diagnosis
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Sarcomas arising in DFSP

General
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Case reports
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Treatment
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Micro description
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Pathophysiology
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Fibrosarcoma arising in DFSP - DFSP cells trap fat cells, fibrosarcoma cells are more uniform

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Fibrosarcoma cells are spindled, uniform and hyperchromatic and arranged in herringbone pattern

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H&E and FISH

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Mitotic activity

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Pleomorphc, tumor cells are pleomorphic and have granular chromatin

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Uncommon finding is myoid nodules containing cells with eosinophilic cytoplasm, present in DFSP or fibrosarcomatous areas, cells are actin+, CD34-, desmin-



End of Skin - Nonmelanocytic tumors > Other tumors of skin > Dermatofibrosarcoma protuberans (DFSP)



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