Skin nonmelanocytic tumor

Other tumors of skin


Topic Completed: 1 September 2012

Minor changes: 15 January 2021

Copyright: 2001-2022,, Inc.

PubMed search: (cutaneous) leiomyosarcoma [title] skin

Christopher S. Hale, M.D.
Page views in 2021: 3,090
Page views in 2022 to date: 135
Cite this page: Hale C. Leiomyosarcoma. website. Accessed January 18th, 2022.
Definition / general
  • Malignant smooth muscle tumor similar to counterparts elsewhere
  • Typically larger than leiomyomas with vascular invasion
  • Recurs, but only rarely metastasizes
  • May be associated with HIV infection
Case reports
Microscopic (histologic) description
  • Cellular lesions of smooth muscle type cells with atypia, necrosis and mitotic activity
  • May have prominent vascular pattern, clear cell features, desmoplasia
Microscopic (histologic) images

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Various images

Positive stains
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