Skin nonmelanocytic tumor

Cutaneous muscle tumors & hamartomas

Atypical smooth muscle tumor



Last author update: 1 September 2012
Last staff update: 8 September 2023

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PubMed Search: Atypical smooth muscle tumor skin

Christopher S. Hale, M.D.
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Cite this page: Hale C. Atypical smooth muscle tumor. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/skintumornonmelanocyticLMS.html. Accessed February 22nd, 2024.
Definition / general
  • Superficial dermal based smooth muscle tumor which is biologically different from deep leiomyosarcoma
  • Typically larger than leiomyomas with vascular invasion
  • Recurs, but only rarely metastasizes
  • May be associated with HIV infection
Case reports
Microscopic (histologic) description
  • Cellular lesions of smooth muscle type cells with atypia, necrosis and mitotic activity
  • May have prominent vascular pattern, clear cell features, desmoplasia
Microscopic (histologic) images

Images hosted on other servers:

Subcutaneous spindle cell neoplasm

Spindle cells and osteoclast-like giant cells

SMA+ and CD68+

Positive stains
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