Skin nonmelanocytic tumor

Cutaneous muscle tumors & hamartomas


Last author update: 1 September 2012
Last staff update: 26 April 2023

Copyright: 2001-2023,, Inc.

PubMed search: (cutaneous) leiomyosarcoma [title] skin

Christopher S. Hale, M.D.
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Cite this page: Hale C. Leiomyosarcoma. website. Accessed June 4th, 2023.
Definition / general
  • Malignant smooth muscle tumor similar to counterparts elsewhere
  • Typically larger than leiomyomas with vascular invasion
  • Recurs, but only rarely metastasizes
  • May be associated with HIV infection
Case reports
Microscopic (histologic) description
  • Cellular lesions of smooth muscle type cells with atypia, necrosis and mitotic activity
  • May have prominent vascular pattern, clear cell features, desmoplasia
Microscopic (histologic) images

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Various images

Positive stains
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