Soft tissue
Fibroblastic / myofibroblastic tumors
Calcifying fibrous tumor

Topic Completed: 1 July 2012

Revised: 21 November 2019

Copyright: 2002-2018,, Inc.

PubMed Search: Calcifying fibrous tumor

Komal Arora, M.D.
Page views in 2019: 4,596
Page views in 2020 to date: 715
Cite this page: Arora K. Calcifying fibrous tumor. website. Accessed February 24th, 2020.
Definition / general
  • Benign fibrous lesion with abundant hyalinized collagen, psammomatous or dystrophic calcifications and lymphocytic infiltration
  • Also called calcifying fibrous pseudotumor
  • First described in 1993 (Am J Surg Pathol 1993;17:502)
Clinical features
Case reports
  • Excision, rarely recurs
Gross description
  • Well circumscribed but unencapsulated, variable size, may infiltrate into surrounding tissue, may have gritty cut surface
Gross images

Images hosted on other servers:

Gray-white tumor with whorled cut surface

Microscopic (histologic) description
  • Paucicellular fibroblastic proliferation with lymphocytes (possibly lymphoid follicles), plasma cells, eosinophils, mast cells, dense collagenous tissue, varying degrees of calcification
  • Border is often at least partially infiltrative
Microscopic (histologic) images

Images hosted on PathOut server:

AFIP images

vary in size

inflammation is

Adrenal gland tumor
has paucicellular fibrous
proliferation with focal

Contributed by Mark R. Wick, M.D.

Case of the Week #249

Omental tumor

Images hosted on other servers:

Psammoma body and lymphoplasmacytic infiltrate

Hyalinized collagen with psammoma body

Positive stains
Electron microscopy description
  • Immature fibroblastic cells, collagen fibrils, dystrophic and psammomatous calcifications
Differential diagnosis
Additional references
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