Soft tissue
Fibroblastic / myofibroblastic tumors
Calcifying fibrous tumor

Author: Komal Arora, M.D. (see Authors page)

Revised: 12 August 2016, last major update July 2012

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: Calcifying fibrous tumor

Cite this page: Calcifying fibrous tumor. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/softtissuecalcifyingfibrous.html. Accessed December 11th, 2016.
Definition / General
  • Benign fibrous lesion with abundant hyalinized collagen, psammomatous or dystrophic calcifications and lymphocytic infiltration
  • Also called calcifying fibrous pseudotumor
  • First described in 1993 (Am J Surg Pathol 1993;17:502)
Clinical Features
Case Reports
Treatment
  • Excision, rarely recurs
Gross Description
  • Well circumscribed but unencapsulated, variable size, may infiltrate into surrounding tissue, may have gritty cut surface
Gross Images

Images hosted on other servers:

Gray-white tumor with whorled cut surface

Micro Description
  • Paucicellular fibroblastic proliferation with lymphocytes (possibly lymphoid follicles), plasma cells, eosinophils, mast cells, dense collagenous tissue, varying degrees of calcification
  • Border is often at least partially infiltrative
Micro Images

Images hosted on PathOut servers:

Courtesy of
Mark R. Wick, M.D.

Micro-
calcifications
vary in size

Lympho-
plasmacytic
inflammation is
characteristic

Adrenal gland tumor
has paucicellular fibrous
proliferation with focal
microcalcifications



Omental tumor



Images hosted on other servers:

Psammoma body and lymphoplasmacytic infiltrate

Hyalinized collagen with psammoma body

Positive Stains
Electron Microscopy Description
  • Immature fibroblastic cells, collagen fibrils, dystrophic and psammomatous calcifications
Electron Microscopy Images

Images hosted on Nature servers:

Spindle cells

Differential Diagnosis
Additional References