Testis and epididymis
Germ cell tumors
Regressed germ cell tumor

Senior Author: Debra Zynger, M.D.
Editorial Board Member: Maria Tretiakova, M.D., Ph.D.
Mit D. Shah, B.S.
Debra Zynger, M.D.

Topic Completed: 1 August 2018

Revised: 22 August 2019

Copyright: 2018-2019, PathologyOutlines.com, Inc.

PubMed Search: Regressed germ cell tumor testicular

Mit D. Shah, B.S.
Debra Zynger, M.D.
Page views in 2018: 443
Page views in 2019 to date: 924
Cite this page: Shah MD, Zynger D. Regressed germ cell tumor. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/testisregressedgct.html. Accessed October 16th, 2019.
Definition / general
Essential features
  • Regressed germ cell tumor
  • Burned out germ cell tumor
  • Burnt out germ cell tumor
Clinical features
Radiology description
Radiology images

Images hosted on other servers:

Scrotal ultrasound
(fig 3B)

primary with
metastasis (fig 2B)

Prognostic factors
  • Posttreatment disease free survival rate: 29% at 5 years and 12% at 10 years (J Urol 2009;182:2303)
  • No difference in prognosis between complete and partial regression (J Urol 2009;182:2303)
  • In context of regressed germ cell tumor with metastasis, pure seminoma has a more favorable prognosis (J Urol 2009;182:2303)
  • No data is available comparing prognosis of regressed versus nonregressed testicular germ cell tumors
Case reports
Gross description
Gross images

Contributed by Debra Zynger, M.D.

Regressed testicular germ cell tumor

Microscopic (histologic) description
Microscopic (histologic) images

Contributed by Debra Zynger, M.D.


Acellular matrix

Small vessels


Germ cell neoplasia in situ

OCT3 / 4



Molecular / cytogenetics description
  • Identification of isochromosome 12p by FISH can confirm a testicular germ cell tumor metastasis although immunohistochemistry is more commonly used and has wider availability
Sample pathology report
  • Left testicle and spermatic cord, radical inguinal orchiectomy:
    • Scar (1.5 cm) and germ cell neoplasia in situ, consistent with regressed germ cell tumor (see synoptic report, pTis NX)
    • Comment: the germ cell neoplasia in situ expresses OCT3/4, D2-40, CD117 and PLAP
Differential diagnosis
Board review question #1
Germ cell neoplasia in situ is found adjacent to a scar, consistent with regressed germ cell tumor. Positive expression using which of the following can confirm the germ cell neoplasia in situ?

  1. AFP
  2. Beta hCG
  3. CD30
  4. CK7
  5. OCT3 / 4
Board review answer #1
E. OCT3 / 4

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Board review question #2
What is the most common tumor subtype in a partially regressed testicular germ cell tumor?

  1. Choriocarcinoma
  2. Embryonal carcinoma
  3. Seminoma
  4. Teratoma
  5. Yolk sac tumor
Board review answer #2
C. Seminoma

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