CNS tumor
Sellar region tumors

Topic Completed: 1 January 2006

Minor changes: 21 January 2021

Copyright: 2002-2021,, Inc.

PubMed Search: Pituicytoma

Nat Pernick, M.D.
Page views in 2020: 1,594
Page views in 2021 to date: 438
Cite this page: Pernick N. Pituicytoma. website. Accessed March 9th, 2021.
Definition / general
  • Also called infundibuloma
  • Rare low grade glioma of sella and suprasellar region
  • May be derived from neurohypophyseal pituicytes (a specialized glial cell of the stalk and posterior lobe of the pituitary gland with supportive role for vasopressin and oxytocin producing neurons)
  • Mean age 48 years, range 30 - 83 years; 6 of 9 were men
  • Visual symptoms, headaches or hypopituitarism
Radiology description
  • Solid, discrete, contrast enhancing masses within sella or suprasellar space
Case reports
  • Total resection
  • May recur if incompletely excised
Microscopic (histologic) description
  • Sheet, fascicles or storiform arrangement of plump bipolar spindle cells with abundant, slightly fibrillar eosinophilic cytoplasm without vacuoles and without granulation, mildly pleomorphic and oval nuclei with pinpoint nucleoli
  • Rich capillary network with vessels often surrounded by radiating spindle cells
  • No infiltration of adjacent tissue, no Rosenthal fibers, no granular bodies, no granular axonal dilations (Herring bodies, normally present in neurohypophysis), no / rare mitotic figures
Positive stains
Negative stains
Electron microscopy description
  • Bipolar spindle cells with abundant intermediate filaments
  • No meningothelial or ependymal features
Differential diagnosis
Additional references
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