Salivary glands
Primary salivary gland neoplasms

Topic Completed: 1 September 2012

Minor changes: 13 April 2021

Copyright: 2003-2021,, Inc.

PubMed Search: Myoepithelioma[TI] salivary glands

Adriana Handra-Luca, M.D.
Page views in 2020: 12,672
Page views in 2021 to date: 4,476
Cite this page: Handra-Luca A. Myoepithelioma. website. Accessed April 15th, 2021.
Definition / general
Clinical features
  • 1% of salivary gland tumors, more common in parotid and minor salivary gland tumors
  • Mean age 54 years, also children
  • May be associated with myasthenia gravis
  • Recur locally if incomplete removal
  • Imaging: well circumscribed, lobulated, inhomogeneous enhancement, apparent diffusion coeficient on MRI different from Warthin tumor and similar to pleomorphic adenoma (AJNR Am J Neuroradiol 2009;30:591)
Case reports
Clinical images

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Plasmacytoid myoepithelioma of minor salivary glands

Gross description
  • Up to 5 cm; encapsulated, may have cystic change
Microscopic (histologic) description
  • Solid (nonmyxoid), myxoid (pleomorphic adenoma-like), reticular (canalicular-like) or mixed patterns of myoepithelial cells with no ductal differentiation
  • Plasmacytoid cells, spindle cells, clear cells, epithelioid cells, oncocytic cells, hyaline cells
  • Mucoid or hyaline stroma, rarely lipomatous
  • Rarely synchronous with adenoid cystic carcinoma
  • Rarely with intracapsular invasion
Microscopic (histologic) images

Images hosted on other servers:

Plasmacytoid myoepithelioma of palate

Plasmacytoid myoepithelioma of minor salivary glands

Myoepithelioma of minor salivary gland of cheek

Cytology description
  • Nuclear grooves, intranuclear cytoplasmic inclusions, nuclear striations (zebra lines), myxoid matrix; no marked pleiomorphism, no mitoses
Negative stains
Molecular / cytogenetics description
  • Aneuploid or diploid, 12q alterations, chromosome 8q involved in malignant phenotype
Differential diagnosis
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