Soft tissue

So called fibrohistiocytic

Deep fibrous histiocytoma

Last author update: 1 August 2012
Last staff update: 25 January 2023

Copyright: 2002-2024,, Inc.

PubMed Search: Deep fibrous histiocytoma

Christopher S. Hale, M.D.
Vijay Shankar, M.D.
Page views in 2023: 20,294
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Cite this page: Hale CS, Shankar V. Deep fibrous histiocytoma. website. Accessed February 23rd, 2024.
Definition / general
  • Fibrous histiocytoma of subcutaneous tissue, deep soft tissue or parenchymal organs, with no dermal involvement (Am J Surg Pathol 1994;18:677, Am J Surg Pathol 1990;14:801, Stanford Medicine)
  • Rare painless lesions, < 1% of fibrohistiocytic tumors
  • Usually adult males > 25 years (range 6 - 84 years)
  • Usually extremities, head and neck, trunk; rarely in deep soft tissue of retroperitoneum, mediastinum or pelvis
Case reports
Clinical images

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Nodule in arch of foot

Gross description
  • Well circumscribed with pseudocapsule, typically 4 cm (range 0.5 to 25 cm), variable hemorrhage
Microscopic (histologic) description
  • Prominent storiform pattern of uniform spindle cells with ill defined eosinophilic cytoplasm and bland, elongated or plump vesicular nuclei with no atypia
  • Often hemangiopericytoma-like vasculature
  • Scattered lymphocytes, either multinucleated giant cells, osteoclastic giant cells or foam cells in 59%
  • Usually less than 5 mitotic figures / 10 HPF
  • Stroma is myxoid or hyaline
  • Borders are non-infiltrative, with no trapping of fat cells
  • Necrosis or angiolymphatic invasion are rare
Microscopic (histologic) images

AFIP images

Circumscribed tumor with no trapped fat

Cellular tumor

Tumor with more fibrous stroma

Foam cells help distinguish from DFSP

Focal storiform pattern and cellular uniformity

Hemangiopericytoma-like vascular pattern

Case #360

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Various images

Positive stains
Negative stains
Differential diagnosis
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