Soft tissue

So called fibrohistiocytic

Deep benign fibrous histiocytoma



Topic Completed: 1 August 2012

Minor changes: 30 November 2020

Copyright: 2002-2021, PathologyOutlines.com, Inc.

PubMed Search: Deep benign fibrous histiocytoma

Christopher S. Hale, M.D.
Vijay Shankar, M.D.
Page views in 2020: 5,755
Page views in 2021 to date: 8,059
Cite this page: Hale CS, Shankar V. Deep benign fibrous histiocytoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/skintumornonmelanocyticdeepbfh.html. Accessed October 24th, 2021.
Definition / general
  • Benign fibrous histiocytoma of subcutaneous tissue, deep soft tissue or parenchymal organs, with no dermal involvement (Am J Surg Pathol 1994;18:677, Am J Surg Pathol 1990;14:801, Stanford Medicine)
  • Rare painless lesions, < 1% of fibrohistiocytic tumors
  • Usually adult males > 25 years (range 6 - 84 years)
  • Usually extremities, head and neck, trunk; rarely in deep soft tissue of retroperitoneum, mediastinum or pelvis
Case reports
Treatment
Clinical images

Images hosted on other servers:

Nodule in arch of foot

Gross description
  • Well circumscribed with pseudocapsule, typically 4 cm (range 0.5 to 25 cm), variable hemorrhage
Microscopic (histologic) description
  • Prominent storiform pattern of uniform spindle cells with ill defined eosinophilic cytoplasm and bland, elongated or plump vesicular nuclei with no atypia
  • Often hemangiopericytoma-like vasculature
  • Scattered lymphocytes, either multinucleated giant cells, osteoclastic giant cells or foam cells in 59%
  • Usually less than 5 mitotic figures / 10 HPF
  • Stroma is myxoid or hyaline
  • Borders are non-infiltrative, with no trapping of fat cells
  • Necrosis or angiolymphatic invasion are rare
Microscopic (histologic) images

AFIP images

Circumscribed tumor with no trapped fat

Cellular tumor

Tumor with more fibrous stroma

Foam cells help distinguish from DFSP



Focal storiform pattern and cellular uniformity

Hemangiopericytoma-like vascular pattern



Case #360



Images hosted on other servers:

Various images

Positive stains
Negative stains
Differential diagnosis
Back to top
Image 01 Image 02