Soft tissue
So called fibrohistiocytic
Deep benign fibrous histiocytoma

Topic Completed: 1 August 2012

Minor changes: 21 July 2020

Copyright: 2002-2019,, Inc.

PubMed Search: Deep benign fibrous histiocytoma

Christopher S. Hale, M.D.
Vijay Shankar, M.D.
Page views in 2019: 5,866
Page views in 2020 to date: 2,992
Cite this page: Hale CS, Shankar V. Deep benign fibrous histiocytoma. website. Accessed August 8th, 2020.
Definition / general
  • Benign fibrous histiocytoma of subcutaneous tissue, deep soft tissue or parenchymal organs, with no dermal involvement (Am J Surg Pathol 1994;18:677, Am J Surg Pathol 1990;14:801, Stanford Medicine)
  • Rare painless lesions, < 1% of fibrohistiocytic tumors
  • Usually adult males > 25 years (range 6 - 84 years)
  • Usually extremities, head and neck, trunk; rarely in deep soft tissue of retroperitoneum, mediastinum or pelvis
Case reports
Clinical images

Images hosted on other servers:

Nodule in arch of foot

Gross description
  • Well circumscribed with pseudocapsule, typically 4 cm (range 0.5 to 25 cm), variable hemorrhage
Microscopic (histologic) description
  • Prominent storiform pattern of uniform spindle cells with ill defined eosinophilic cytoplasm and bland, elongated or plump vesicular nuclei with no atypia
  • Often hemangiopericytoma-like vasculature
  • Scattered lymphocytes, either multinucleated giant cells, osteoclastic giant cells or foam cells in 59%
  • Usually less than 5 mitotic figures / 10 HPF
  • Stroma is myxoid or hyaline
  • Borders are non-infiltrative, with no trapping of fat cells
  • Necrosis or angiolymphatic invasion are rare
Microscopic (histologic) images

Images hosted on PathOut servers:

Circumscribed tumor with no trapped fat

Cellular tumor

Tumor with more fibrous stroma

Foam cells help distinguish from DFSP

Focal storiform pattern and cellular uniformity

Hemangiopericytoma-like vascular pattern

Case of the Week #360

Images hosted on other servers:

Various images

Positive stains
Negative stains
Differential diagnosis
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