Soft tissue

Smooth muscle


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Last staff update: 25 January 2023

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PubMed Search: Leiomyoma[TI] general pathology

Vijay Shankar, M.D.
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Cite this page: Shankar V. Leiomyoma. website. Accessed June 8th, 2023.
Definition / general
  • Cutaneous and pilar tumors are described in the Skin chapter
  • Some tumors previously considered to be leiomyomas are actually GI stromal (GIST) tumors
  • See also colon-tumor, esophagus, uterus chapters
  • Skin and subcutis; also deep soft tissue, uterus (most common neoplasm in women)
  • Patients with multiple cutaneous leiomyomas may have autosomal dominant disorder (described under Cutaneous leiomyoma)
Case reports
Gross description
  • Deep tumors are well circumscribed, gray-white; usually large at presentation, up to 15 cm; may have myxoid change
Gross images

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Leiomyoma of deep soft tissue

Leiomyoma of deep soft tissue

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Myxoid subcutaneous tumor

Microscopic (histologic) description
  • Bundles or fascicles of spindled cells with eosinophilic and possibly fibrillary cytoplasm
  • Nuclei are blunt ended and elongated with fine chromatin, indistinct nucleolus and variable cytoplasmic vacuole at one end
  • Minimal atypia
  • Few mitotic figures
  • No coagulative tumor necrosis
Microscopic (histologic) images

AFIP images

Oblong nuclei have rounded ends

Bundles of elongate
cells with eosinophilic
cytoplasm and oblong nuclei

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Calcified leiomyoma

Negative stains
Differential diagnosis
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