Soft tissue
Peripheral nerve
Other benign

Topic Completed: 1 November 2012

Minor changes: 22 October 2020

Copyright: 2002-2021,, Inc.

PubMed Search: Perineurioma [title]

Vijay Shankar, M.D.
Page views in 2020: 9,598
Page views in 2021 to date: 616
Cite this page: Shankar V. Perineurioma. website. Accessed January 22nd, 2021.
Definition / general
  • Uncommon benign tumor of peripheral nerve composed primarily of perineurial cells, first described in 1978
  • Adults, more common in females
  • Extremities and trunk most common sites
Case reports
Clinical images

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Endobronchial nodule

Gross description
  • Well circumscribed, variable size, usually NOT associated with a nerve
Microscopic (histologic) description
  • Bland, elongated cells in parallel bundles, resembles neurofibroma or pacinian neurofibroma; may have storiform growth
  • May have collagenous stroma with pericellular cracking / clefting
  • No atypia, rare mitotic figures
  • Suspect if myxoid lesion of soft tissue with storiform or fascicular growth pattern
Microscopic (histologic) images

Contributed by Mark R. Wick, M.D.



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Median nerve


Site unknown

Endobronchial nodule in 53 year old woman

Positive stains
Negative stains
Electron microscopy description
  • Non-branching, thin cytoplasmic processes, coated by external lamina, joined at ends by tight junctions, few organelles, actin and vimentin filaments, numerous pinocytotic vesicles
Electron microscopy images

Contributed by Mark R. Wick, M.D.


Molecular / cytogenetics description
  • Monosomy 22, deletion of 22q11-13.1
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