Stains & molecular markers
Myeloperoxidase


Topic Completed: 1 June 2005

Minor changes: 10 December 2020

Copyright: 2002-2021, PathologyOutlines.com, Inc.

PubMed Search: Myeloperoxidase [title]

Nat Pernick, M.D.
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Cite this page: Pernick N. Myeloperoxidase. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainsmyeloperoxidase.html. Accessed June 19th, 2021.
Definition / general
  • Staining is either immunohistochemistry (IHC) or enzyme cytochemistry - enzyme cytochemistry is most sensitive and specific stain for myeloid leukemias and granulocytic sarcoma
  • Stains neutrophils strongly (diffuse granular pattern), other granulocytes variably
Positive staining - normal
  • Neutrophils, eosinophils, monocytes (variable), AML-M1, M2, microgranular M3
  • Granulocytic sarcoma
Negative staining
  • Lymphocytes, ALL
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