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General
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Terminology
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Epidemiology
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Features
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Treatment and prognosis
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Case reports
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Clincal images
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MRI, courtesy of Dr. Mark R. Wick

Gross images
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No distinct gross features

Micro description
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Micro images
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Courtesy of Dr. Mark R. Wick

"Subgross" image

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Various images

Lobules are distended by monomorphic cells

Intracytoplasmic lumina

Fibroadenoma with LCIS and invasive lobular carcinoma (contributed by Semir Vranic, MD)

Core biopsy

Involving adenosis

Involving sclerosing adenosis (Fig 4A/B)

With adjacent infiltrating lobular carcinoma

Comparison with low grade DCIS

Various images


Lobules are distended by monomorphic cells

With comedonecrosis

Prominent intracytoplasmic vacuoles

Various images


Lobular neoplasia:

Involving foci of florid hyperplasia

Monotonous cells obliterate lumina

Involving a micropapilloma


AFIP Fascicle images (3rd Series):

Normal epithelium is replaced by uniform cells that fill acini, individual glands are round and discrete

Discrete acini have haphazardly arranged monomorphic cells with scant cytoplasm and dark nuclei

Monomorphic cells have no specific orientation to basement membrane

Pagetoid spread of LCIS cells into normal acini (arrow)

Type A (central) and type B (peripheral) cells

Involvement of duct and lobule, with pagetoid extension beneath duct epithelium in lower left

Layer of LCIS cells beneath attenuated ductal epithelium

Cytoplasmic vacuoles (arrows)

Signet ring cells

Serrated (sawtooth) pattern with LCIS involvement of ducts and ductules only

Cloverleaf pattern in atrophic TDLU in post-menopausal woman

Resembles invasive carcinoma but has alveolar pattern of LCIS

Merging with DCIS

With microinvasion (linear strands or single cells)


Stains:

Mucicarmine+

Fig 3a: Factor VIII, Fig 3b: low MIB1 staining

LCIS is E-cadherin negative

E-cadherin staining of mixed LCIS and DCIS

E-cadherin negative (Fig. G) and p-120 catenin positive (Fig. J)

Cytology description
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Virtual slides
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LCIS

DCIS and LCIS

Videps
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Positive stains
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Negative stains
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Molecular / cytogenetics description
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Differential diagnosis
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End of Breast malignant, males, children > In situ carcinoma > Lobular carcinoma in situ (LCIS)



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