Skin - Nonmelanocytic tumors
Other tumors of skin
Granular cell tumor

Author: Christopher Hale, M.D. (see Authors page)

Revised: 4 October 2016, last major update September 2012

Copyright: (c) 2001-2016,, Inc.

PubMed search: cutaneous granular cell [title] tumor

Cite this page: Granular cell tumor. website. Accessed October 27th, 2016.
Definition / General
  • Also known as Abrikossoff's tumor
  • 2 / 3 of cases: are oral, occur in people of African descent, occur in women
  • Skin is most common extraoral site
  • 1 - 3% of soft tissue cases are malignant (Am J Surg Pathol 1998;22:779)
Case Reports
Gross Description
  • Nodule or plaque; rarely ulcerates
Gross Images
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Arising on toe

Micro Description
  • Infiltrative tumor composed of large polyhedral cells with abundant granular cytoplasm and small, central nuclei
  • Often pseudoepitheliomatous hyperplasia, lysosomal inclusions (pustulo-ovoid bodies of Milian) usually present (J Cutan Pathol 2007;34:405)
Micro Images
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Positive Stains
Negative Stains
Differential Diagnosis