Skin tumor - Nonmelanocytic - Granular cell tumor of skin

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Skin - Nonmelanocytic tumors

Other tumors of skin

Granular cell tumor of skin

Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 14 September 2012, last major update September 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
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● Also known as Abrikossoff's tumor
● 2/3 of cases: are oral, occur in people of African descent, occur in women
● Skin is most common extraoral site
● 1-3% of soft tissue cases are malignant (Am J Surg Pathol 1998;22:779)

Case reports
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● 54 year old with toe lesion (Dermatol Res Pract 2010;2010:184125)

Gross description
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● Nodule or plaque, rarely ulcerates

Gross images
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Arising on toe

Micro description
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● Infiltrative tumor composed of large polyhedral cells with abundant granular cytoplasm and small, central nuclei
● Often pseudoepitheliomatous hyperplasia, lysosomal inclusions (pustulo-ovoid bodies of Milian) usually present (J Cutan Pathol 2007;34:405)

Micro images
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H&E

Positive stains
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● PAS-D, Sudan Black, S100, NSE
● Variable staining for vimentin and CD68

Negative stains
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● HMB45, AE1/AE3, EMA, desmin

Differential diagnosis
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● Melanoma
● Squamous cell carcinoma
● Histiocytic lesions

End of Skin - Nonmelanocytic tumors > Other tumors of skin > Granular cell tumor of skin

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