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Skin - Nonmelanocytic tumors
Other tumors of skin
Granular cell tumor

Author: Christopher Hale, M.D. (see Authors page)

Revised: 4 October 2016, last major update September 2012

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PubMed search: cutaneous granular cell [title] tumor

Table of Contents
Definition / general | Case reports | Gross description | Gross images | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Negative stains | Differential diagnosis
Cite this page: Granular cell tumor. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/skintumornonmelanocyticgct.html. Accessed June 20th, 2018.
Definition / general
  • Also known as Abrikossoff's tumor
  • 2 / 3 of cases: are oral, occur in people of African descent, occur in women
  • Skin is most common extraoral site
  • 1 - 3% of soft tissue cases are malignant (Am J Surg Pathol 1998;22:779)
Case reports
Gross description
  • Nodule or plaque; rarely ulcerates
Gross images
Images hosted on other servers:

Arising on toe

Microscopic (histologic) description
  • Infiltrative tumor composed of large polyhedral cells with abundant granular cytoplasm and small, central nuclei
  • Often pseudoepitheliomatous hyperplasia, lysosomal inclusions (pustulo-ovoid bodies of Milian) usually present (J Cutan Pathol 2007;34:405)
Microscopic (histologic) images
Images hosted on other servers:

H&E

Positive stains
Negative stains
Differential diagnosis
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