Skin nonmelanocytic tumor
Other tumors of skin

Topic Completed: 1 September 2012

Minor changes: 14 July 2020

Copyright: 2001-20202016,, Inc.

PubMed search: leiomyoma [title] skin

Christopher S. Hale, M.D.
Page views in 2019: 2,177
Page views in 2020 to date: 2,054
Cite this page: Hale C. Leiomyoma. website. Accessed October 26th, 2020.
Definition / general
  • Divided into lesions of nipple or scrotum, pilar leiomyoma or solitary angioleiomyoma (vascular leiomyoma) usually in subcutis
  • May be very painful

Familial cutaneous leiomyomatosis (Reed syndrome):
Microscopic (histologic) description
  • Intersecting smooth muscle fascicles
  • May have scattered bizarre hyperchromatic nuclei (symplastic leiomyoma)
  • No atypia, no mitotic activity, no necrosis

Pilar leiomyoma:
  • Dermal intersecting fascicles of eosinophilic spindle cells with plump, cigar shaped nuclei with dermal collagen bundles
Microscopic (histologic) images
Images hosted on PathOut server:

Courtesy of Dr. Angel Fernandez-Flores, M.D., Ph.D, Hospital El Bierzo and Clinica Ponferrada, Spain:

Various images

Positive stains
Negative stains
Differential diagnosis
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