Skin nonmelanocytic tumor

Other tumors of skin


Topic Completed: 1 September 2012

Minor changes: 9 November 2020

Copyright: 2001-2022,, Inc.

PubMed search: leiomyoma [title] skin

Christopher S. Hale, M.D.
Page views in 2021: 3,682
Page views in 2022 to date: 283
Cite this page: Hale C. Leiomyoma. website. Accessed January 28th, 2022.
Definition / general
  • Divided into lesions of nipple or scrotum, pilar leiomyoma or solitary angioleiomyoma (vascular leiomyoma) usually in subcutis
  • May be very painful

Familial cutaneous leiomyomatosis (Reed syndrome):
Microscopic (histologic) description
  • Intersecting smooth muscle fascicles
  • May have scattered bizarre hyperchromatic nuclei (symplastic leiomyoma)
  • No atypia, no mitotic activity, no necrosis

Pilar leiomyoma:
  • Dermal intersecting fascicles of eosinophilic spindle cells with plump, cigar shaped nuclei with dermal collagen bundles
Microscopic (histologic) images

Contributed by Angel Fernandez-Flores, M.D., Ph.D.

Various images

Positive stains
Negative stains
Differential diagnosis
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