Skin nonmelanocytic tumor

Cutaneous muscle tumors & hamartomas


Last author update: 1 September 2012
Last staff update: 9 April 2024 (update in progress)

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PubMed search: leiomyoma [title] skin free full text[sb]

Christopher S. Hale, M.D.
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Cite this page: Hale C. Leiomyoma. website. Accessed April 15th, 2024.
Definition / general
  • Divided into lesions of nipple or scrotum, pilar leiomyoma or solitary angioleiomyoma (vascular leiomyoma) usually in subcutis
  • May be very painful
  • Familial cutaneous leiomyomatosis (Reed syndrome):
Clinical features
Case reports
Clinical images

Images hosted on other servers:

Multiple asymptomatic, hyperkeratotic nodules on leg

Gray-brown macules on face


Microscopic (histologic) description
  • Intersecting smooth muscle fascicles
  • May have scattered bizarre hyperchromatic nuclei (symplastic leiomyoma)
  • No atypia, no mitotic activity, no necrosis
  • Pilar leiomyoma:
    • Dermal intersecting fascicles of eosinophilic spindle cells with plump, cigar shaped nuclei with dermal collagen bundles
Microscopic (histologic) images

Contributed by Angel Fernandez-Flores, M.D., Ph.D.

Various images

Positive stains
Negative stains
Molecular / cytogenetics description
Differential diagnosis
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