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Cervix
Benign / nonneoplastic lesions
Placental site nodule


Branko Perunovic D.M.

Topic Completed: 1 May 2007

Revised: 27 December 2018, last major update May 2007

Copyright: (c) 2007-2017, PathologyOutlines.com, Inc.

PubMed Search: Placental site nodule


Branko Perunovic D.M.
Page views in 2018: 291
Page views in 2019 to date: 253
Table of Contents
Definition / general | Gross description | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Negative stains | Differential diagnosis | Additional references
Cite this page: Perunovic B. Placental site nodule. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixplacentalsitenod.html. Accessed August 21st, 2019.
Definition / general
Gross description
  • May be visible but usually small
  • Single or multiple
Microscopic (histologic) description
  • Resembles trophoblasts in chorion lava
  • Well defined hyalinized lesion, variably cellular, immediately below mucosa, composed of extravillous (intermediate) trophoblast cells with abundant amphophilic, glycogen rich or eosinophilic cytoplasm with vacuoles, irregular nuclei with degenerative features and possible atypic
  • Occasional inflammatory cells, rare / no mitotic figures
Microscopic (histologic) images

Images hosted on PathOut server:

Nodule just below surface
with sparsely
cellular stroma

Cytoplasmic vacuoles
and nuclear
enlargement

Negative stains
  • Ki67 ( < 8% positivity)
Differential diagnosis
Additional references
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