Table of Contents
Definition / general | Gross description | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Negative stains | Differential diagnosis | Additional referencesCite this page: Perunovic B. Placental site nodule. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixplacentalsitenod.html. Accessed December 7th, 2019.
Definition / general
- Ages 27 to 45 years
- Incidental finding; benign (Am J Surg Pathol 1990;14:1001)
Gross description
- May be visible but usually small
- Single or multiple
Microscopic (histologic) description
- Resembles trophoblasts in chorion lava
- Well defined hyalinized lesion, variably cellular, immediately below mucosa, composed of extravillous (intermediate) trophoblast cells with abundant amphophilic, glycogen rich or eosinophilic cytoplasm with vacuoles, irregular nuclei with degenerative features and possible atypic
- Occasional inflammatory cells, rare / no mitotic figures
Microscopic (histologic) images
Negative stains
- Ki67 ( < 8% positivity)
Differential diagnosis
- Cartilaginous tumors
- Hyalinizing squamous cell carcinoma: definite squamous cells, atypia, HPL negative
- Placental site trophoblastic tumor: larger, has mitotic activity, not degenerative
Additional references
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