Placental site nodule

Cervix
Benign / nonneoplastic lesions
Placental site nodule

Author: Branko Perunovic, M.D. (see Authors page)

Revised: 19 April 2017, last major update May 2007

Copyright: (c) 2007-2017, PathologyOutlines.com, Inc.

PubMed Search: Placental site nodule

Table of Contents

Cite this page: Placental site nodule. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixplacentalsitenod.html. Accessed June 24th, 2017.

Definition / general

Ages 27 to 45 years
Incidental finding; benign (Am J Surg Pathol 1990;14:1001)

Gross description

May be visible but usually small
Single or multiple

Microscopic (histologic) description

Resembles trophoblasts in chorion lava
Well defined hyalinized lesion, variably cellular, immediately below mucosa, composed of extravillous (intermediate) trophoblast cells with abundant amphophilic, glycogen rich or eosinophilic cytoplasm with vacuoles, irregular nuclei with degenerative features and possible atypic
Occasional inflammatory cells, rare / no mitotic figures

Microscopic (histologic) images

Images hosted on PathOut server:

Nodule just below surface
with sparsely
cellular stroma

Cytoplasmic vacuoles
and nuclear
enlargement

Positive stains

Keratin, PLAP, inhibin alpha, CK18 , HLA-G, p63

Negative stains

Ki67 ( < 8% positivity)

Differential diagnosis

Cartilaginous tumors
Hyalinizing squamous cell carcinoma: definite squamous cells, atypia, HPL negative
Placental site trophoblastic tumor: larger, has mitotic activity, not degenerative

Additional references

Hum Pathol 1999;30:687