Benign / nonneoplastic lesions
Placental site nodule

Author: Branko Perunovic, M.D. (see Authors page)

Revised: 19 April 2017, last major update May 2007

Copyright: (c) 2007-2017, PathologyOutlines.com, Inc.

PubMed Search: Placental site nodule

Cite this page: Placental site nodule. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixplacentalsitenod.html. Accessed October 15th, 2018.
Definition / general
Gross description
  • May be visible but usually small
  • Single or multiple
Microscopic (histologic) description
  • Resembles trophoblasts in chorion lava
  • Well defined hyalinized lesion, variably cellular, immediately below mucosa, composed of extravillous (intermediate) trophoblast cells with abundant amphophilic, glycogen rich or eosinophilic cytoplasm with vacuoles, irregular nuclei with degenerative features and possible atypic
  • Occasional inflammatory cells, rare / no mitotic figures
Microscopic (histologic) images

Images hosted on PathOut server:

Nodule just below surface
with sparsely
cellular stroma

Cytoplasmic vacuoles
and nuclear

Negative stains
  • Ki67 ( < 8% positivity)
Differential diagnosis
Additional references