Cervix
Benign / nonneoplastic epithelial lesions
Placental site nodule
Author: Branko Perunovic, D.M.
Topic Completed: 1 May 2007
Minor changes: 30 November 2020
Copyright: 2007-2020, PathologyOutlines.com, Inc.
PubMed Search: Placental site nodule
Table of Contents
Definition / general | Gross description | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Negative stains | Differential diagnosis | Additional referencesCite this page: Perunovic B. Placental site nodule. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixplacentalsitenod.html. Accessed December 5th, 2020.
Definition / general
- Ages 27 to 45 years
- Incidental finding; benign (Am J Surg Pathol 1990;14:1001)
Gross description
- May be visible but usually small
- Single or multiple
Microscopic (histologic) description
- Resembles trophoblasts in chorion lava
- Well defined hyalinized lesion, variably cellular, immediately below mucosa, composed of extravillous (intermediate) trophoblast cells with abundant amphophilic, glycogen rich or eosinophilic cytoplasm with vacuoles, irregular nuclei with degenerative features and possible atypic
- Occasional inflammatory cells, rare / no mitotic figures
Microscopic (histologic) images
AFIP images
Nodule just below surface
with sparsely
cellular stroma
Cytoplasmic vacuoles
and nuclear
enlargement
Negative stains
- Ki67 ( < 8% positivity)
Differential diagnosis
- Cartilaginous tumors
- Hyalinizing squamous cell carcinoma: definite squamous cells, atypia, HPL negative
- Placental site trophoblastic tumor: larger, has mitotic activity, not degenerative
Additional references
