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Pleura
Mesothelial tumors
Mesothelioma

Reviewer: Vaidehi Avadhani, M.D. (see Reviewers page)
Revised: 16 December 2013, last major update November 2013
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
PubMed Search: Mesothelioma [title]

See subtypes below: generalclear cell variantdeciduoid variantdesmoplasticepithelioidmixedsarcomatoid

General

General
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Epidemiology
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Etiology
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Clinical features
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Diagnosis
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Laboratory
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Radiology
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Prognostic factors
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Case reports
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Treatment
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Gross description
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Gross images
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Tumor mass arises from visceral pleura

Micro description
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Micro images
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Epithelioid cells with round nuclei

Mesothelioma cells infiltrating into adipose tissue

Enlarged nuclei with prominent nucleoli

Spindle cells or plump rounded cells forming gland-like configurations


Calretinin, CK5/6

WT1 staining

D2-40, MOC31, TTF1

Cytology description
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Cytology images
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Parakeratotic-like cell

Positive stains
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Negative stains
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Electron microscopy description
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Molecular / cytogenetics description
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Differential diagnosis
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Additional references
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Clear cell variant

General
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Terminology
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Epidemiology
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General
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Micro description
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General
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Round to polygonal epithelioid cells

Positive stains
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Negative stains
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Electron microscopy description
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Electron microscopy images
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Numerous slender and long surface microvilli

Differential diagnosis
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Deciduoid variant

General
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Terminology
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Epidemiology
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Sites
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Radiologic images
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Lobulated mass in upper region of left hemithorax

Case reports
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Micro description
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Micro images
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Uniform, large cohesive cells

Marked loss of cellular cohesion

Strong nuclear and cytoplasmic positivity for calretinin

Involving and lining the adipose tissue

Pleural tumor

Cytology description
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Positive stains
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Negative stains
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Electron microscopy description
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Electron microscopy images
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Neoplastic cells remain barely attached

Molecular / cytogenetics images
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Comparative genomic hybridization

Differential diagnosis
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Additional references
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Desmoplastic

General
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Case reports
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Micro description
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Micro images
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Storiform pattern

Figures 5A/5B

Positive stains
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Negative stains
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Electron microscopy description
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Differential diagnosis
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Epithelioid

Epidemiology
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Micro description
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Micro images
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Pseudotubular structure

Various patterns

Cuboidal cells with moderate cytoplasm

Nuclear features

Papillary morphology


Keratin, calretinin, D2-40

Alcian blue, PAS-D

Cytology description
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Positive stains
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Negative stains
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Electron microscopy description
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Differential diagnosis
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Mixed

General
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Epidemiology
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Case reports
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Clinical images
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Low density mass in liver

Gross images
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Firm, white lesion

Micro description
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Micro images
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Biphasic tumor

H&E and immunostains

Epithelial immunostains

Sarcomatoid immunostains

Various stains


Stains for epithelial-mesenchymal transition

MiR-205 ISH

Differential diagnosis
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Sarcomatoid

General
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Epidemiology
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Case reports
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Treatment
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Clinical images
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Small left pleural effusion

Clumped calcification and pleural effusion

Coarse, clumped calcification

Gross images
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Gross distribution of disease

Micro description
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Micro images
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Infiltrative spindle cells

Various images

Various images

Peritoneal tumor


AE1-AE3, CAM5.2, calretinin

WT1, D2-40

Strong and diffuse cytoplasmic immunoreactivity

Cytology description
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Positive stains
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Negative stains
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Electron microscopy description
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Differential diagnosis
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Additional references
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End of Pleura > Mesothelial tumors > Mesothelioma



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