CNS & pituitary tumors

Gliomas, glioneuronal tumors, and neuronal tumors

Neuronal and mixed neuronal-glial tumors

Papillary glioneuronal tumor

Last author update: 1 May 2014
Last staff update: 17 August 2020

Copyright: 2002-2023,, Inc.

PubMed Search: Papillary glioneuronal tumor [title]

Eman Abdelzaher, M.D., Ph.D.
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Cite this page: Abdelzaher E. Papillary glioneuronal tumor. website. Accessed January 29th, 2023.
Definition / general
  • Rare, low grade biphasic neoplasm characterized by pseudopapillae lined by glial cells with interpapillary neuronal elements
  • Favorable outcome suggests that it corresponds to WHO grade I
  • First described by Komori et al. (Am J Surg Pathol 1998;22:1171)
  • Age: young adults
  • Sex: no gender predilection
  • Cerebral hemisphere
  • > Temporal lobe
Radiology description
  • Supratentorial, discrete, contrast enhancing
  • Often cystic with occasional cyst mural nodule pattern
Radiology images

Images hosted on other servers:

Heterogeneously enhancing mass in pineal gland

Case reports
  • Complete surgical resection
  • Favorable clinical outcome
Microscopic (histologic) description
  • Biphasic pattern with glial and neuronal components
  • Glial component: small uniform glial cells line pseudopapillae with hyalinized vascular cores; no atypia or mitosis
  • Neuronal component: interpapillary zone is occupied by neurocytes with uniform nuclei and occasional perinuclear halos; occasionally ganglion and ganglioid cells are admixed
  • Vascular proliferation and necrosis are exceptional
  • The surrounding brain tissue shows gliosis
Cytology description
  • Nonspecific, uniform cells
Immunohistochemistry & special stains
Electron microscopy description
  • Three cell types: astrocytic, neuronal, glioneuronal progenitor cells
Differential diagnosis
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