Liver & intrahepatic bile ducts

Other malignancies

Undifferentiated embryonal sarcoma



Last author update: 1 February 2012
Last staff update: 1 June 2022

Copyright: 2002-2024, PathologyOutlines.com, Inc.

PubMed Search: Undifferentiated embryonal sarcoma

Deepali Jain, M.D.
Page views in 2023: 4,097
Page views in 2024 to date: 2,379
Cite this page: Jain D. Undifferentiated embryonal sarcoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/livertumorundiffsarcoma.html. Accessed July 13th, 2024.
Definition / general
Case reports
Treatment
Clinical images

Images hosted on other servers:

Adult with 16 cm tumor

Gross description
  • 10 - 30 cm, solitary, well demarcated, soft tumor with cystic, gelatinous, hemorrhagic and necrotic foci
Gross images

Case #134

10 year old girl with 15 cm tumor

Microscopic (histologic) description
  • Variably cellular tumor with anaplastic, spindled / oval cells with prominent hyaline globules and ill defined borders within pseudocapsule
  • Nuclei have stippled chromatin, inconspicuous nucleoli
  • Variably myxoid stroma with numerous thin walled veins
  • Also bizarre tumor cells with prominent eosinophilic cytoplasm and PAS+ diastase resistant hyaline globules
  • Extramedullary hematopoiesis common, frequent mitotic activity
  • Note that trapped hepatocytes and bile duct structures are present at periphery
  • Adults may have partial smooth muscle differentiation (Hum Pathol 2003;34:246)
Microscopic (histologic) images

Case #134
Various images Various images Various images Various images Various images

Various images


PAS diastase

PAS diastase

Alpha-1-antitrypsin

Alpha-1-antitrypsin



Contributed by @liverwei on Twitter
Undifferentiated embryonal sarcoma Undifferentiated embryonal sarcoma Undifferentiated embryonal sarcoma Undifferentiated embryonal sarcoma

Undifferentiated embryonal sarcoma



Contributed by @RaulSGonzalezMD on Twitter
Undifferentiated embryonal sarcoma Undifferentiated embryonal sarcoma Undifferentiated embryonal sarcoma

Undifferentiated embryonal sarcoma

Positive stains
Negative stains
Electron microscopy description
  • Hyaline globules are lysosomal and possibly apoptotic bodies
Differential diagnosis
Back to top
Image 01 Image 02