Liver & intrahepatic bile ducts

Other malignancies

Undifferentiated embryonal sarcoma

Topic Completed: 1 February 2012

Minor changes: 17 March 2021

Copyright: 2002-2021,, Inc.

PubMed Search: Undifferentiated embryonal sarcoma[TI] liver[TI]

Deepali Jain, M.D.
Page views in 2020: 2,763
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Cite this page: Jain D. Undifferentiated embryonal sarcoma. website. Accessed December 3rd, 2021.
Definition / general
Case reports
Clinical images

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Adult with 16 cm tumor

Gross description
  • 10 - 30 cm, solitary, well demarcated, soft tumor with cystic, gelatinous, hemorrhagic and necrotic foci
Gross images

Case #134

10 year old girl with 15 cm tumor

Microscopic (histologic) description
  • Variably cellular tumor with anaplastic, spindled / oval cells with prominent hyaline globules and ill defined borders within pseudocapsule
  • Nuclei have stippled chromatin, inconspicuous nucleoli
  • Variably myxoid stroma with numerous thin walled veins
  • Also bizarre tumor cells with prominent eosinophilic cytoplasm and PAS+ diastase resistant hyaline globules
  • Extramedullary hematopoiesis common, frequent mitotic activity
  • Note that trapped hepatocytes and bile duct structures are present at periphery
  • Adults may have partial smooth muscle differentiation (Hum Pathol 2003;34:246)
Microscopic (histologic) images

Case #134

Various images

PAS diastase


Images hosted on other servers:

Adult with adipophilin - positive vesicles

Adult with 16 cm tumor

Positive stains
Negative stains
Electron microscopy description
  • Hyaline globules are lysosomal and possibly apoptotic bodies
Differential diagnosis
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