Salivary glands
Primary salivary gland neoplasms
Canalicular adenoma

Topic Completed: 1 September 2012

Minor changes: 21 May 2021

Copyright: 2003-2021,, Inc.

PubMed Search: Canalicular adenoma salivary

Adriana Handra-Luca, M.D., Ph.D.
Page views in 2020: 6,461
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Cite this page: Handra-Luca A. Canalicular adenoma. website. Accessed June 23rd, 2021.
Definition / general
Clinical features
  • Usually arises from minor salivary glands of upper lip or palate (Ann Diagn Pathol 1998;2:224); also parotid gland (Mod Pathol 2002;15:298)
  • Female predominance for palate tumors
  • Usually ages 50+ years
  • Recurrence is uncommon
  • Symptoms: pain, multifocal swelling or synchronous bilateral tumors, ulceration
Case reports
  • Excision, radiotherapy
Gross description
  • Often encapsulated, 22% multifocal
  • Tumor may be received as fragmented specimen
Microscopic (histologic) description
  • Bilayered strands or ribbons of columnar cells with loose, well vascularized stroma
  • Often basaloid cells or trabecular features
  • May infiltrate capsule and exhibit extracapsular tumor islands
  • Often cystic change, apocrine, mucous or pigmented cells (Histopathology 1999;35:502)
Microscopic (histologic) images

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GFAP staining

Positive stains
Differential diagnosis
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