• Tumors with differentiation between neuroblastoma and ganglioneuroma
  
• Usually young children but also adults
  
• Common in retroperitoneum or mediastinum (similar to ganglioneuroma), but NOT common in adrenal gland
  
• Better prognosis than neuroblastoma
  

Ganglioneuroblastoma (not classified)

• Also called composite schwannian stroma rich / stroma dominant; stroma poor neuroblastic tumor, immature
  
• Nodules may represent aggressive tumor clones
  
• Poorer prognosis (unfavorable histology) compared to intermixed variant
  

• Hemorrhagic neuroblastoma nodules
  

• Abrupt demarcation of neuroblastic component (stroma poor) from ganglioneuroma (stroma dominant) or ganglioneuroblastoma, intermixed (stroma rich) with pushing borders and variable fibrous pseudocapsule
  
• Ganglioneuroma or ganglioneuroblastoma, intermixed component may be at periphery
  
• Neuroblastic component may resemble lymphocytes
  
  

• Also called schwannian stroma rich neuroblastic tumor, imperfect
  
• Favorable histology (better prognosis) compared to nodular variant of ganglioneuroblastoma
  

• No distinct hemorrhagic nodule
  

• Random intermingling (i.e. infiltrative interface) of neuroblastic nests and ganglioneuromatous component
  
• Neuroblasts may have variable differentiation; usually abundant neuropil
  
• Ganglioneuroma / ganglioneuroblastoma component is > 50% of volume
  

• Differentiating neuroblastoma: similar, neuroblastomas have > 5% ganglion cells, but 50% or less ganglioneuroma / ganglioneuroblastoma component
  

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