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See   abdominopelvic sarcomaappendiceal tumorbreast carcinomacarcinoid tumorcervical carcinomacolon carcinomadesmoplastic small round cell tumorendometrial adenocarcinomaendometrial stromal sarcomagallbladder adenocarcinomagastric carcinomagastrointestinal stromal tumorhepatocellular carcinomaintrahepatic cholangiocarcinomaKrukenberg tumorlung carcinomamelanomaneuroendocrine carcinomapancreatic acinar cell carcinomapancreatic ductal carcinomarenal cell carcinoma   below

General
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Abdominopelvic sarcoma of perivascular epithelioid cells metastatic to ovary

General
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Micro description
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Micro images
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Clear cells resembling renal cell carcinoma

High power

Nodal metastases HMB45+

Positive stains
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Negative stains
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Appendiceal tumor

Gross images
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Cystic locules filled with jelly-like material




Breast carcinoma metastatic to ovary

General
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Gross images
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Multiple confluent nodules

Small cysts

Micro images
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Ductal type

Lobular type

Positive stains
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Negative stains
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Carcinoid tumor

Gross images
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Smaller tumor is solid; larger tumor has numerous cysts

Contributed by: Dr. Hayam Aiad, Menoufiya University (Egypt)

Micro images
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Contributed by: Dr. Hayam Aiad, Menoufiya University (Egypt)




Cervical carcinoma metastatic to ovary

General
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Gross images
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Several cysts and solid white tissue

Micro images
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Large pseudocysts contain necrotic material

Cyst lined by neoplastic squamous epithelium




Colon carcinoma metastatic to ovary

General
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Gross description
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Gross images
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Yellow necrotic tissue

Shaggy necrotic tissue

Multilocular cystic tumor

Micro description
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Micro images
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Extensive "dirty" necrosis

Mucinous epithelium

"Dirty" necrotic debris

Cyst lined by papillae (upper)

With luteinization of stroma


Various images

CDX2, P504S and beta-catenin staining

Positive stains
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Differential diagnosis
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Desmoplastic small round cell tumor metastatic to ovary

General
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Gross description
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Micro description
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Micro images
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Discrete aggregates of small cells

Small spindle shaped cells

Trabeculae surrounded by diffuse cellular proliferation

Resembling metastatic breast carcinoma

Gland-like structures contain mucin

Desmin

Positive stains
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Electron description
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Endometrial adenocarcinoma

Micro images
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Endometrioid type




Endometrial stromal sarcoma

Micro images
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Uniform nuclei and scanty cytoplasm

Characteristic arterioles




Gallbladder adenocarcinoma

Micro images
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Cystically dilated glands




Gastric carcinoma (intestinal type) metastatic to ovary

General
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Gross description
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Micro description
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Micro images
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Cystic glands




Gastrointestinal stromal tumor metastatic to ovary

General
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Gross description
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Micro description
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Positive stains
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Negative stains
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Differential diagnosis
=========================================================================



Hepatocellular carcinoma

Gross images
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Pale yellow and green nodules




Intrahepatic cholangiocarcinoma metastatic to ovary

General
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Micro description
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Positive stains
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Krukenberg tumor

General
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Case reports
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Gross description
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Gross images
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Bilateral bosselated masses

Focal hemorrhage

Multiloculated cystic neoplasm

Large right ovarian mass

Micro description
=========================================================================

Micro images
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Signet-ring cells distributed irregularly

Numerous signet-ring cells with eccentric nuclei

Edematous stroma

Tubular

Mucicarmine


Signet ring cells




Lung carcinoma metastatic to ovary

General
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Case reports
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Gross description
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Gross images
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Multiple tumor nodules

Micro description
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Micro images
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Trabecular pattern

H&E, CEA

Positive stains
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Negative stains
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Melanoma metastatic to ovary

General
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Gross description
=========================================================================

Gross images
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Bosselated external surface

Pale yellow with focal hemorrhage

Micro description
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Micro images
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Resembling juvenile granulosa cell tumor

Resembling small cell carcinoma of hypercalcemic type

HMB-45

Positive stains
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Negative stains
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Electron microscopy description
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Differential diagnosis
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Neuroendocrine carcinoma metastatic to ovary

Gross images
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Ileal tumor




Pancreatic acinar cell carcinoma metastatic to ovary

General
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Micro description
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Pancreatic ductal carcinoma metastatic to ovary

General
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Gross description
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Gross images
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Resembles primary mucinous cystic tumor

Micro description
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Micro images
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Resembles slightly atypical mucinous cystadenoma

Surface implant with desmoplastic stroma

Microglandular pattern




Renal cell carcinoma metastatic to ovary

General
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Case reports
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Gross description
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Micro description
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Micro images
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Abundant clear cytoplasm; dilated sinusoids

Various images

Positive stains
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Negative stains
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Differential diagnosis
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End of Ovary tumor > Other tumors not specific to ovary > Metastases to ovary



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