Thyroid gland
Papillary carcinoma
Nodular fasciitis-like stroma variant

Author: Shahidul Islam, M.D., Ph.D. (see Authors page)

Revised: 1 February 2017, last major update March 2009

Copyright: (c) 2003-2017,, Inc.

PubMed Search: nodular fasciitis-like stroma papillary carcinoma
Cite this page: Nodular fasciitis-like stroma variant. website. Accessed May 21st, 2018.
Definition / general
  • Papillary carcinoma with prominent stromal reaction (but not the features of diffuse sclerosing variant)
  • Rare, first described in 1991 (Am J Clin Pathol 1991;95:309)
  • Similar behavior as classic papillary carcinoma; at presentation, 25% have nodal metastases, 13% have metastases to surrounding structures, no distant metastases (J Laryngol Otol 2006;120:338)
  • Stroma may be reactive (Histopathology 1992;21:577)
Case reports
Microscopic (histologic) description
  • Exuberant proliferation of fibroblasts / myofibroblasts with short fascicles and mucoid matrix, collagen and extravasated red blood cells, resembling fibromatosis or nodular fasciitis
  • Malignant epithelial component grows in narrow tubules, clustered glands or solid sheets, with variable squamous differentiation and papillae, has classic papillary nuclear features, but may be obscured by prominent stroma (Endocr Pathol 2002;13:219)
Microscopic (histologic) images

Images hosted on PathOut server:

Nodular fasciitis-like stroma

Images hosted on other servers:

Classic papillary nuclear features

Various images

Cytology description
Negative stains
Electron microscopy description
  • Myofibroblastic features
Differential diagnosis