Skin nonmelanocytic tumor
Lymphoma and related disorders (see also Lymphoma chapter)
Lymphoid hyperplasia

Topic Completed: 1 June 2012

Minor changes: 15 October 2020

Copyright: 2003-2021,, Inc.

PubMed search: Lymphoid hyperplasia [title]

Christopher S. Hale, M.D.
Page views in 2020: 4,146
Page views in 2021 to date: 810
Cite this page: Hale C. Lymphoid hyperplasia. website. Accessed March 5th, 2021.
Definition / general
  • Nonspecific finding
  • May be due to trauma, infection, arthropods
Clinical images

Contributed by Mark R. Wick, M.D.

Breast skin

Gross description
  • Solitary nodules or plaques
Microscopic (histologic) description
  • Lymphocytic and histiocytic infiltrate with tingible body macrophages, plasma cells, eosinophils
  • Often germinal cells or lymphoid follicles, hyperplastic vessels or epidermal hyperplasia
  • Usually spares epidermis
Microscopic (histologic) images

Contributed by Mark R. Wick, M.D.

Breast skin

Various images

Florid idiopathic


Positive stains
  • Both kappa and lambda light chain expression, both B and T cells
Differential diagnosis
  • MALT lymphoma: marginal zone cells, Dutcher bodies, sheets of plasma cells
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