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Mediastinum

Cystic lesions

Thymomas - cystic

Reviewer: Hanni Gulwani, M.D. (see Reviewers page)
Revised: 24 February 2013, last major update December 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
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● Cystic degeneration of thymoma in anterosuperior mediastinum

Clinical features
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● Associated with paraneoplastic syndromes

Gross description
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● Encapsulated, uniloculated or multiloculated
● Variable cystic contents

Micro description
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● Bland proliferation of thymic epithelium (spindle or polygonal cells) present in cyst wall
● Usually no cholesterol granulomas, no cartilage, no smooth muscle

Micro images
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Spindle cell thymoma (type A) has cysts of various sizes

Differential diagnosis
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● Thymic cyst: no/minimal thymic epithelial cells in cyst wall; no evidence of thymoma

End of Mediastinum > Cystic lesions > Thymomas - cystic

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