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Soft tissue
Skeletal muscle
Botryoid variant of embryonal rhabdomyosarcoma

Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 6 December 2013, last major update July 2009
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.

Terminology
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Clinical features
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Treatment and prognosis
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Gross description
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Gross images
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Clusters of edematous, grape-like masses that protrude into lumen of hollow organs
Micro description
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Micro images
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Figures 1 and 2
Figure 3
Figure 4
Figures 5 and 6
Figs 1&2: Polypoid or lobulated masses of cells covered by mucosa, with underlying hypercellular zone of poorly differentiated cells (cambium layer)
Fig 3: Tumor may have only focal cambium layer, and consist primarily of paucicellular edematous tissue with scattered undifferentiated or atypical large cells
Fig 4: Tumor with sheets of round or spindle cells resembling benign polyp or fibroinflammatory lesion
Figs 5&6: Deep foci of hypercellularity is common with round or spindled undifferentiated cells mixed with differentiating rhabdomyoblasts


Vaginal tumor

Condensation of tumor cells in subepithelial zone
Positive stains
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End of Soft tissue > Skeletal muscle > Botryoid variant of embryonal rhabdomyosarcoma


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