Cystic thymoma

Last author update: 1 December 2012
Last staff update: 15 August 2022

Copyright: 2003-2023,, Inc.

PubMed Search: Thymomas cystic mediastinum

Hanni Gulwani, M.B.B.S.
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Cite this page: Gulwani H. Cystic thymoma. website. Accessed June 1st, 2023.
Definition / general
  • Cystic degeneration of thymoma in anterosuperior mediastinum
Clinical features
  • Associated with paraneoplastic syndromes
Gross description
  • Encapsulated, uniloculated or multiloculated
  • Variable cystic contents
Microscopic (histologic) description
  • Bland proliferation of thymic epithelium (spindle or polygonal cells) present in cyst wall
  • Usually no cholesterol granulomas, no cartilage, no smooth muscle
Differential diagnosis
  • Thymic cyst:
    • No / minimal thymic epithelial cells in cyst wall; no evidence of thymoma
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