Testis & paratestis

General

WHO classification


Editorial Board Member: Bonnie Choy, M.D.
Deputy Editor-in-Chief: Maria Tretiakova, M.D., Ph.D.
Debra L. Zynger, M.D.

Last author update: 14 February 2023
Last staff update: 14 February 2023

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PubMed Search: Testis tumors WHO classification

Debra L. Zynger, M.D.
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Cite this page: Zynger DL. WHO classification. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/testistestclassif.html. Accessed March 29th, 2024.
Definition / general
  • WHO classification of tumors of the urinary and male genital organs
  • Currently on 5th edition, published in 2022
Major updates
  • Germ cell tumors derived from germ cell neoplasia in situ:
    • Teratoma with primitive neuroectodermal tumor (PNET) is now called teratoma with embryonic type neuroendocrine differentiation
  • Sex cord stromal tumors:
    • Signet ring pattern of Sertoli cell tumor is now listed as a separate tumor called signet ring stromal tumor
    • Myoid gonadal stromal tumor changed from a provisional entity to a confirmed entity
  • Paratesticular mesothelial tumors:
    • Well differentiated papillary mesothelioma was renamed well differentiated papillary mesothelial tumor
WHO (2022) (ICD-O morphology terms if different)
Germ cell tumors derived from germ cell neoplasia in situ
Germ cell tumors unrelated to germ cell neoplasia in situ
Sex cord stromal tumors of the testis
Ovarian type tumors of the collecting ducts and rete testis
Tumors of the collecting duct and rete testis
  • Adenoma of the collecting ducts and rete testis (adenoma)
  • Adenocarcinoma of the collecting ducts and rete testis (adenocarcinoma)

Paratesticular mesothelial tumors
Tumors of the epididymis
Metastatic tumors
Board review style question #1

Spermatocytic tumor, shown in the image above, is an example of which of the following categories of testicular tumors?

  1. Germ cell tumors derived from germ cell neoplasia in situ
  2. Germ cell tumors unrelated to germ cell neoplasia in situ
  3. Sex cord stromal tumors
  4. Tumor containing both germ cell and sex cord stromal elements
Board review style answer #1
B. Germ cell tumors unrelated to germ cell neoplasia in situ. Spermatocytic tumor is a germ cell tumor that is not derived from germ cell neoplasia in situ. Most germ cell tumors such as seminoma are thought to be derived from the precursor lesion germ cell neoplasia in situ. Spermatocytic tumor is not a sex cord stromal tumor and does not have sex cord stromal elements.

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Reference: Testis & paratestis - WHO classification
Board review style question #2

Seminoma, shown in the image above, is an example of which of the following categories of testicular tumors?

  1. Germ cell tumors derived from germ cell neoplasia in situ
  2. Germ cell tumors unrelated to germ cell neoplasia in situ
  3. Sex cord stromal tumors
  4. Tumor containing both germ cell and sex cord stromal elements
Board review style answer #2
A. Germ cell tumors derived from germ cell neoplasia in situ. Seminoma is thought to be derived from the precursor lesion germ cell neoplasia in situ. It is not a sex cord stromal tumor and does not contain sex cord stromal elements.

Comment Here

Reference: Testis & paratestis - WHO classification
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