Lymph nodes & spleen, nonlymphoma

Lymph node-nonspecific findings

Granulomatous inflammation

Topic Completed: 1 June 2006

Minor changes: 6 August 2020

Copyright: 2003-2021,, Inc.

PubMed Search: Granulomatous inflammation[TI] lymph node

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Cite this page: DePond W. Granulomatous inflammation. website. Accessed October 21st, 2021.
Definition / general
  • Due to infection (atypical mycobacteria is common), foreign bodies, secondary response to malignancy
  • Helpful diagnostic features include presence and type of necrosis; presence and type of giant cells; size, shape and distribution of granulomas; other associated changes
  • These lymph nodes should be cultured
Case reports
  • 69 year old woman with granulomatous reaction around cholesterol-like clefts, apparently due to draining fluid from an ovarian mucinous cystadenoma (Arch Pathol Lab Med 1985;109:1124)
Gross images

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Extensive involvement by granuloma and fibrosis

Microscopic (histologic) images

Contributed by Dr. Mark R. Wick

Necrotizing granuloma

AFIP images

Necrotizing granulomatous lymphadenitis

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Granduloma due to lymphangiogram contrast media in lymph node

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